Aglan 15 - zikuonetsa, contraindications, mlingo, mavuto

Zomwe zatsimikiziridwa

Aglan 15, chogwiritsidwa ntchito chomwe ndi meloxicam, ndi cha gulu la non-steroidal anti-inflammatory drugs (NSAIDs). Ilinso ndi analgesic ndi antipyretic effect, ndipo imapezeka pamankhwala.

Aglan 15 - mankhwala awa ndi chiyani?

Aglan 15 ndi mankhwala osagwiritsa ntchito steroidal odana ndi kutupa. Ilinso ndi analgesic ndi antipyretic kwenikweni. Zomwe zimagwiritsidwa ntchito ndi meloxicam, zomwe zimalepheretsa ntchito ya cyclooxygenase, makamaka cyclooxygenase-2 (COX-2) ndi cyclooxygenase-1 (COX-1).

Agalan 15 - chizindikiro chogwiritsidwa ntchito

Kukonzekera kumagwiritsidwa ntchito makamaka pochiza anthu okalamba, anthu ovulala, ogwira ntchito za buluu komanso othamanga omwe kale anali othamanga. Zizindikiro zogwiritsira ntchito Agalan 15 ndi matenda monga:

1. nyamakazi ndi matenda aakulu. Zimaphatikizapo ziwalo ndi ziwalo. Ngati chithandizo cha nyamakazi sichinachiritsidwe, kuwonongeka kwa mafupa ndi nthawi zina ngakhale imfa. Matendawa amayamba chifukwa cha matenda a mitsempha, tendon, mafupa ndi cartilage. Matendawa amayambanso chifukwa cha majini, kukanika kwa chitetezo cha mthupi komanso nthawi zina komanso kupanikizika kwambiri.
2. ankylosing spondylitis ndi matenda otupa a msana, omwe zizindikiro zake ndi kyphosis ndi kulemala. Komabe, matendawa amatha kukhudzanso chiuno, phewa, maso, mtima ndi mapapo. Mwina chifukwa cha matendawa ndi majini, immunological, chilengedwe ndi bakiteriya matenda. Zizindikiro zoyamba za matendawa ndi ululu wochepa wammbuyo womwe umatuluka m'matako.
3. Matenda a osteoarthritis ndi amodzi mwa matenda omwe amapezeka kwambiri mu locomotor system. Zimayamba chifukwa cha kusokonezeka kwa cartilage ya articular - zonse zokhudzana ndi ubwino ndi kuchuluka kwake. Zizindikiro za matendawa ndi ululu ndi kuuma kwa mgwirizano, zomwe zimasokoneza mizere yake ndikuchepetsa kuyenda kwake. Zotsatira zake ndi kulumala ndi kuwonongeka kwa moyo wabwino.

Aglan 15 - zochita

The yogwira mankhwala a Aglan 15, monga ena sanali steroidal odana ndi yotupa mankhwala, linalake ndipo tikulephera biosynthesis ndi prostaglandins. Mayamwidwe ake wathunthu kumachitika pambuyo mu mnofu jekeseni. Meloxicam imamangiriza ku mapuloteni a plasma ndikulowa mu synovial fluid, pomwe imafika pafupifupi theka la plasma.

Chiwalo chomwe chimayang'anira kwambiri ntchito ya mankhwalawa ndi chiwindi. Melkosicam imatulutsidwa m'chiwindi ndi ndowe, zonse mofanana. Zimatengedwa bwino kuchokera m'mimba. Pambuyo pakamwa, kuchuluka kwambiri m'magazi kumachitika mkati mwa maola 5-6 mutatha makonzedwe, komanso kukhazikika mkati mwa masiku 3-5 mutagwiritsa ntchito mankhwalawa.

Aglan 15 - contraindications

Aglan 15 sayenera kutengedwa ndi anthu omwe ali ndi:

1. hypersensitivity kwa meloxicam,
2. hypersensitivity ku zinthu zofanana ndi meloxicam,
3. masewera a mphumu
4. mphuno ya polypy,
5. angioedema,
6. ming'oma pambuyo potenga NSAIDs,
7. ming'oma itatha kumwa acetylsalicylic acid,
8. matenda a hemostatic,
9. kutenga anticoagulants,
10. magazi m'mimba
11. trimester yachitatu ya mimba.

Zotsutsana ndi kutenga Aglan 15 ndi:

1. zilonda zam`mimba matenda - yogwira pokonza mankhwala sayenera kugwiritsidwa ntchito ndi anthu yogwira kapena mobwerezabwereza zilonda zam`mimba matenda. Kulephera kutero kungakwiyitse chigawo cha m’mimba kapena cha m’mimba, kuchititsa ululu woyaka m’mimba umene umatuluka kuchokera pachifuwa kupita ku mchombo. Zimayamba chifukwa cha asidi m'mimba kukumana ndi chilonda kapena bala m'mimba. Kugwiritsa ntchito Aglan 15 pankhaniyi kungakhale ndi zotsatira zoyipa pa thanzi.
2. Kulephera kwakukulu kwa chiwindi - kuwonetseredwa ndi kuwonongeka kwadzidzidzi kwa chiwindi. Zitha kuchitika chifukwa cha matenda a HBV, HAV, HCV, chifukwa cha poyizoni wamankhwala komanso momwe thupi limayendera ku chiwindi cha thrombosis kapena matenda amitsempha. Kulephera kwa chiwindi sikudziwika msanga chifukwa nthawi zambiri sikupweteka.
3. Kulephera kwaimpso kwambiri kwa odwala omwe sakulandira dialysis - chizindikiro cha matendawa ndi kuwonongeka kwadzidzidzi kwa chiwindi. Ndiye pali kuwonjezeka magazi creatinine ndende. Wodwalayo amayamba kutulutsa mkodzo wochepa, amasanza, amatsekula m'mimba, alibe madzi okwanira komanso amapsa. Kulephera kwa impso nthawi zambiri kumachitika chifukwa cha masoka osiyanasiyana, monga nkhondo, zivomezi. Zomwe zimayambitsa zikhoza kukhala matenda ndi nephritis. Kuphatikiza apo, imathanso kuyambitsidwa ndi mankhwala osagwiritsa ntchito steroidal odana ndi kutupa komanso mankhwala azitsamba amtundu wokayikitsa.
4. Kulephera kwa mtima kosalamulirika ndi mkhalidwe womwe mtima umapopa magazi ochepa kupita ku ziwalo zina. Zotsatira zake, ziwalozo zimakhala ndi mpweya wochepa ndipo sizingathe kugwira ntchito bwino. Matendawa amapezeka mofulumira. Zomwe zimayambitsa zimakhala matenda osiyanasiyana amtima, nthawi zambiri matenda a ischemic magazi.

Aglan 15 - mlingo

Mankhwalawa amaperekedwa ngati jekeseni. Mlingo wovomerezeka ndi 7,5-15 mg / tsiku. Mu matenda monga nyamakazi ya nyamakazi kapena ankylosing spondylitis, mlingo woyenera ndi 15 mg / tsiku. Majekeseniwo amawathira mkati mwa minyewa kupita kumtunda kwa chiuno. jakisoni amagwiritsidwa ntchito mosinthana - mwachitsanzo kamodzi kumanzere ndi kamodzi m'matako kumanja. Kwa sciatica, mankhwalawa amatha kuonjezera ululu panthawi yoyamba.

Mlingo wa mankhwalawa umadaliranso zaka za wodwalayo. Magulu apadera a odwala ndi okalamba, anthu omwe ali ndi vuto laimpso, anthu omwe ali ndi vuto la chiwindi ndi ana. Malinga ndi malingaliro a wopanga, mlingo wa mankhwala omwe angaperekedwe kwa akuluakulu ndi 7,5 mg; Odwala omwe amatha kukhala ndi zotsatira zoyipa amatha kupatsidwa 7,5 mg patsiku.

Mlingo wa dialysis odwala kwambiri aimpso kuwonongeka sayenera upambana theka la ampoule. Komanso, odwala kwambiri aimpso insufficiency sayenera kupatsidwa kukonzekera. Mosiyana ndi zimenezi, pamene aimpso insufficiency ndi zolimbitsa, mlingo sayenera kuchepetsedwa. Chigamulo cha kukula kwa mlingo ndi kusintha kotheka kwa mtengo wake kuyenera kufunsidwa ndi katswiri woyenera. Kuphatikiza apo, palibe maphunziro omwe angatsimikizire chitetezo ndi mphamvu zoperekera Aglan kwa ana 15 ndi achinyamata mpaka zaka 18.

Aglan 15 - zotsatira zoyipa

Aglan 15 ikhoza kuyambitsa kusintha kwa khungu. Odwala omwe amathandizidwa ndi meloxicam amatha kukhala ndi matenda a Stevens-Johnson. Pakhala pali malipoti a epidermal necrolysis. Choncho, musanayambe chithandizo ndi kukonzekera, wodwalayo ayenera kudziwitsidwa kuti zoterezi zikhoza kuchitika. Ndikoyenera kuwonjezera kuti mwayi wa matenda a Stevens-Johnson ndi kupatukana kwa epidermal ndi waukulu kwambiri mkati mwa masabata oyambirira a chithandizo.

Aglan 15, monga ma NSAID ena, imatha kukulitsa serum transaminosis. Komanso, imathanso kusintha zolembera za chiwindi. Pamene kusintha chifukwa cha izo zikutsimikizira kukhala yaitali, ndiye mankhwala ayenera kuyimitsidwa ndi kuyezetsa koyenera kuchitidwa. Zotsatira zoyipa zimatha kukhala zovuta makamaka kwa anthu omwe ali ndi chitetezo chofooka komanso omwe ali ndi thupi lopepuka.

Aglan 15 - zodzitetezera

Kugwiritsa ntchito NSAID kumawonjezera chiopsezo chotaya magazi m'mimba, matenda a zilonda zam'mimba kapena kubowola - kuchuluka kwa mankhwalawa kumapangitsa kuti magazi azituluka. Anthu omwe ali pagulu lachiwopsezochi nthawi zonse azifunsana ndi dokotala pazosankha zilizonse zokhudzana ndi kugwiritsa ntchito mankhwalawa. Gulu ili la odwala nthawi zambiri limalimbikitsidwa kuti amwe mlingo wotsika kwambiri wa Aglan 15.

Ngati zotsatirapo zikuwonekera panthawi ya chithandizo, funsani dokotala mwamsanga. Chenjezo liyenera kuperekedwa kwa odwala omwe akumwa nawo mankhwala omwe angapangitse chiwopsezo cha zilonda kapena kutuluka magazi. oral corticosteroids, anticoagulants, kusankha serotonin reuptake inhibitors kapena antiplatelet mankhwala.

Anthu omwe ali ndi matenda oopsa kwambiri ayenera kulandira chithandizo chamankhwala chapadera panthawi ya mankhwala. Pali chiopsezo chakuti kutenga NSAID zina kungapangitse chiopsezo cha matenda a mtima kapena sitiroko, makamaka kwa ogwiritsa ntchito nthawi yayitali. Anthu omwe akudwala matenda monga:

1. Matenda a mtima (coronary artery disease) - ichi ndi chikhalidwe chomwe mtima umaperekedwa mokwanira ndi mpweya. Chifukwa chake ndi kuchepa kwa mitsempha ya m'mitsempha, yomwe imayang'anira kupereka zakudya ku minofu ya mtima. Matenda a mtima nthawi zambiri amakhala atherosulinosis. Ndilo matenda amtima omwe amapezeka kwambiri m'maiko otukuka kwambiri.
2. kuthamanga kwa magazi kosalamulirika - chifukwa cha matendawa ndi kuthamanga kwa magazi pamakoma a mitsempha. Chotsatira chake, pali kuwonongeka kwa ziwiya ndipo motero ku matenda a mtima. Kuchuluka kwa kuthamanga kwa magazi kumadalira kuchuluka kwa magazi omwe amaponyedwa m'mitsempha komanso kukana kwa mitsempha yozungulira. Matendawa akhoza kukhala asymptomatic kwa nthawi yayitali, ndipo ena mwa iwo ndi mutu wosasunthika, chizungulire ndi mphuno.
3. peripheral arterial matenda - vuto lomwe limapangitsa kuti mitsempha yanu ikhale yopapatiza ndikutsekeka, zomwe zimapangitsa kuti magazi aziyenda. Zimayamba chifukwa cha kuchuluka kwa mafuta m'mitsempha yanu. Zizindikiro za matendawa ndi monga kutopa ndi kufooka kwa miyendo, kupweteka kwa miyendo, kugwedeza kwa mapazi, dzanzi m'manja ndi mapazi, khungu lozizira komanso kusintha kwa khungu.
4. cerebrovascular disease - ndi gulu la matenda omwe chizindikiro chake chimasokoneza kutuluka kwa magazi kumadera ena a ubongo. Matendawa ndi, mwachitsanzo, sitiroko, kukha magazi kwa subarachnoid, aneurysms yaubongo, atherosulinosis yaubongo, thrombosis yaubongo, embolism yaubongo. Matenda akhoza kupha. Zomwe zimapangitsa kuti apangidwe ndi izi: kuthamanga kwa magazi, cholesterol yapamwamba komanso kunenepa kwambiri.

Aglan 15 - kuyanjana ndi mankhwala ena

Kugwiritsa ntchito limodzi ndi Aglan 15 ndi ma NSAID ena kungayambitse zilonda zam'mimba komanso kutuluka magazi. Komanso osavomerezeka kumwa mankhwala osagwiritsa ntchito steroidal odana ndi kutupa ndi oral anticoagulants pa nthawi yomweyo.

Aglan 15, monga ma NSAID ena, imatha kuchepetsa mphamvu ya okodzetsa ndi mankhwala ochepetsa kuthamanga kwa magazi. Chowopseza thanzi, makamaka kwa okalamba ndi anthu omwe ali ndi vuto la aimpso, ndikugwiritsa ntchito munthawi yomweyo, mwachitsanzo, zoletsa za ACE ndi othandizira omwe amaletsa cyclooxygenase. Odwala omwe amamwa mankhwalawa ayenera kukhala opanda madzi.

Kugwiritsa ntchito munthawi yomweyo Aglan 15 ndi mankhwala a antihypertensive kulinso kovulaza. Zotsatira zake, mankhwala a antihypertensive beta-adrenergic blocker sagwira ntchito. NSAIDs nthawi zina kumawonjezera nephrotoxicity ya cyclosporine chifukwa amakhudza aimpso prostaglandins. Anthu omwe amamwa mankhwalawa ayenera kuyang'aniridwa ndi achipatala nthawi zonse - izi zimagwira ntchito makamaka kwa okalamba.