THEammoniémiendi mayeso kuyeza mlingo waammonia mu magazi.

Ammonia imagwira ntchito Kusamalira pH koma ndi chinthu chapoizoni chomwe chiyenera kusinthidwa ndi kuchotsedwa mwamsanga. Ngati alipo ochulukirapo (hyperammoniemie), imakhala yowopsa kwambiri ku ubongo ndipo imatha kuyambitsa chisokonezo (matenda amisala), ulesi ndipo nthawi zina ngakhale chikomokere.

Kaphatikizidwe ake kumachitika makamaka mumatumbo, komanso pamlingo wa aimpso ndi minofu. Kuchepetsa kwake kumachitika m'chiwindi pomwe amasinthidwa kukhala urea, ndiye amachotsedwa mwanjira iyi mumkodzo.

Popeza ichi ndi mankhwala oopsa, ndikofunika kuyesa ammonia pamene mukukayikira kuwonjezeka kwa ndende yake.

Dokotala akhoza kupereka mlingo wake:

• ngati akukayikira a Kusakwanira kwa hepatic

• kupeza zomwe zimayambitsa kusazindikira kapena kusintha kwa khalidwe

• kudziwa zomwe zimayambitsa chikomokere (ndiye zimayikidwa pamodzi ndi mayeso ena, monga shuga wamagazi, chiwindi ndi impso ntchito, electrolytes)

• kuyang'anira mphamvu ya chithandizo cha hepatic encephalopathy (kusokonekera kwa zochitika zamaganizidwe, ntchito ya neuromuscular ndi chidziwitso chomwe chimachitika chifukwa cha kulephera kwa chiwindi kapena pachimake),

Dziwani kuti dokotala akhoza kupempha ammonia mwana wakhanda ngati akukwiya, kusanza, kapena kusonyeza kutopa kwambiri m'masiku oyambirira a kubadwa kwake. Mlingo uwu umachitidwa makamaka akagonekedwa m'chipatala.

Kutsimikiza kwa ammonia kumatha kuchitika m'njira zosiyanasiyana:

• by magazi a arterial, yochitidwa mu mtsempha wa chikazi (m'mimba mwa groin) kapena mtsempha wamagetsi (m'manja)

• ndi magazi a venous, omwe nthawi zambiri amatengedwa chapakati pa chigongono, makamaka pamimba yopanda kanthu

Makhalidwe abwino a ammonia mwa akulu ndi apakati pa 10 ndi 50 µmoles / L (micromoles pa lita) m'magazi otsika.

Miyezo iyi imasiyanasiyana kutengera zitsanzo komanso ndi labotale yomwe ikuwunika. Amakhala otsika pang'ono m'magazi a venous kusiyana ndi magazi odutsa. Amathanso kusiyana ndi kugonana ndipo amakhala ochuluka mwa ana obadwa kumene.

Ngati zotsatira zikuwonetsa kuchuluka kwa ammonia (hyperammonemia), zikutanthauza kuti thupi silingathe kuliphwanya mokwanira ndikulichotsa. Mtengo wokwera ukhoza kulumikizidwa makamaka ndi:

• kulephera chiwindi

• kuwonongeka kwa chiwindi kapena impso

• hypokalemia (kuchepa kwa potaziyamu m'magazi)

• kulephera mtima

• magazi m'mimba

• matenda obadwa nawo omwe amakhudza zigawo zina za urea

• kupsyinjika kwakukulu kwa minofu
• poizoni (mankhwala antiepileptic kapena phalloid amanitis)

Zakudya zokhala ndi mapuloteni ochepa (ochepa mu nyama ndi mapuloteni) ndi mankhwala (arginine, citrulline) omwe amathandiza kuthetsa ammonia akhoza kuperekedwa.