Gawo limodzi mwa magawo atatu a odwala omwe amapezeka ndi khansa yapakhosi ali ndi kachilombo ka human papillomavirus (HPV), yomwe nthawi zambiri imakhudzana ndi khansa ya pachibelekero, inatero Journal of Clinical Oncology.
Matenda a papillomavirus (HPV) ndi amodzi mwa omwe amapezeka kwambiri padziko lapansi. HIV imafalikira makamaka pogonana kudzera mwachindunji kukhudzana mucous nembanemba kumaliseche, komanso khungu lozungulira iwo. Bungwe la World Health Organization (WHO) likuyerekeza kuti mpaka 80 peresenti. Anthu ogonana amakhala ndi kachilombo ka HPV nthawi ina m'miyoyo yawo. Kwa ambiri a iwo ndi zakanthawi. Komabe, pang'onopang'ono zimakhala zosatha, zomwe zimawonjezera chiopsezo chokhala ndi mitundu yosiyanasiyana ya khansa.
Mwa mitundu yopitilira 100 yodziwika bwino (yotchedwa serotypes) ya human papillomavirus (HPV), angapo ndi oyambitsa khansa. Pali mitundu iwiri - HPV16 ndi HPV18, yomwe imayang'anira pafupifupi 70 peresenti. milandu ya khansa ya pachibelekero.
Akatswiri a WHO akuyerekeza kuti matenda a HPV ndi omwe amachititsa pafupifupi 100 peresenti. milandu ya khansa ya pachibelekero, komanso 90 peresenti. Matenda a khansa, 40 peresenti ya khansa ya kunja kwa ziwalo zoberekera - mwachitsanzo, maliseche, nyini ndi mbolo, komanso peresenti inayake ya khansa ya mutu ndi khosi, kuphatikizapo 12% ya khansa ya m'phuno ndi pharynx ndi pafupifupi. 3 peresenti. khansa ya m'kamwa. Palinso kafukufuku wosonyeza kukhudzidwa kwa kachilomboka pakukula kwa khansa ya m'mawere, mapapo ndi prostate.
Kafukufuku waposachedwapa amasonyeza kuwonjezeka kwa chiwerengero cha khansa ya pakhosi ndi laryngeal mogwirizana ndi matenda a HPV. Mpaka pano, kumwa mowa mopitirira muyeso ndi kusuta zakhala zikuonedwa kuti ndizofunikira kwambiri pa khansa imeneyi. Asayansi akukayikira kuti kuwonjezeka kwa HPV kukhudzidwa ndi chitukuko cha khansa imeneyi kumagwirizana ndi ufulu wochuluka wogonana komanso kutchuka kwa kugonana m'kamwa.
Kuyesa ubale pakati pa HPV ndi khansa ya khansa ya mutu ndi khosi, asayansi ochokera ku gulu lapadziko lonse adachita kafukufuku wa odwala 638 omwe akudwala nawo, kuphatikizapo khansa ya m'kamwa (odwala 180), khansa ya oropharynx (odwala 135) , khansa ya m'munsi pharynx / larynx (odwala 247). Adawunikanso odwala omwe ali ndi khansa ya esophageal (anthu 300). Poyerekeza, anthu 1600 athanzi adayesedwa. Onse anali nawo pa kafukufuku wakale waku Europe wokhudzana ndi ubale pakati pa moyo ndi chiopsezo cha khansa - European Prospective Investigation Into Cancer and Nutrition.
Zitsanzo za magazi zomwe zonse zidaperekedwa kumayambiriro kwa kafukufukuyu pomwe anali athanzi adawunikidwa kuti apeze ma antibodies ku mapuloteni a HPV16 komanso ma carcinogenic human papillomavirus subtypes monga HPV18, HPV31, HPV33, HPV45, HPV52, ndi HPV6 ndi HPV11 omwe ndi Chofala kwambiri cha zilonda zam'mimba koma zovuta (zomwe zimatchedwa genital warts), ndipo sizingayambitse khansa ya vulvar.
Zitsanzo za khansa zinali pafupifupi zaka zisanu ndi chimodzi, koma ena anali opitilira zaka 10 asanazindikire.
Zinapezeka kuti pafupifupi 35 peresenti. Odwala khansa ya Oropharyngeal apezeka kuti ali ndi ma antibodies ku mapuloteni ofunikira a HPV 16, ofupikitsidwa ngati E6. Amazimitsa puloteni yomwe imalepheretsa njira ya neoplastic m'maselo ndipo motero imathandizira kukula kwake. Kukhalapo kwa ma antibodies ku mapuloteni a E6 m'magazi nthawi zambiri kumawonetsa kukula kwa khansa.
Poyerekeza, mu gulu lolamulira kuchuluka kwa anthu okhala ndi ma antibodies m'magazi anali 0.6%. Panalibe mgwirizano pakati pa kukhalapo kwawo ndi zotupa zina za mutu ndi khosi zomwe zinaphatikizidwa mu phunziroli.
Ofufuzawo adatsimikiza kuti ubale pakati pa kukhalapo kwa ma antibodies awa ndi khansa ya oropharyngeal udalipo ngakhale kwa odwala omwe magazi adatengedwa zaka zopitilira 10 asanazindikire khansa.
Chochititsa chidwi n'chakuti pakati pa odwala khansa ya oropharyngeal komanso kukhalapo kwa anti-HPV16 antibodies, chiwerengero chochepa cha imfa chifukwa cha zifukwa zosiyanasiyana chinapezeka kusiyana ndi odwala opanda ma antibodies. Zaka zisanu pambuyo pa matendawo, 84 peresenti anali adakali ndi moyo. anthu ochokera ku gulu loyamba ndi 58 peresenti. winayo.
Zotsatira zodabwitsazi zimapereka umboni wina wosonyeza kuti matenda a HPV16 akhoza kukhala chifukwa chachikulu cha khansa ya oropharyngeal, ndemanga wolemba nawo wina Dr. Ruth Travis wa yunivesite ya Oxford.
Sara Hiom wochokera ku Cancer Research UK Foundation adati poyankhulana ndi BBC kuti ma virus a HPV ndi ofala kwambiri.
Kugonana moyenera kumachepetsa chiopsezo chotenga matenda kapena kupatsira wina HPV, koma makondomu sangakutetezeni ku matenda, adatero. Zimadziwika kuti kachilombo kameneka kamene kamakhala pakhungu m'dera lakumaliseche kungakhalenso gwero la matenda.
Hiom anatsindika kuti sizikudziwika ngati katemera omwe panopa akugwiritsidwa ntchito poletsa khansa ya khomo lachiberekero mwa atsikana achichepere (mmodzi wa iwo amavomerezedwanso kuti anyamata ateteze zilonda zam'mimba ndi khansa ya mbolo) angachepetse chiopsezo cha khansa ya oropharyngeal. Ngati kafukufuku akutsimikizira izi, zidzawoneka kuti angagwiritsidwe ntchito kwambiri popewa matenda oopsa a neoplasms. (PAP)
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