June 4, 2010 - Kugwiritsa ntchito ma statins - banja la mankhwala ochepetsa mafuta m'thupi - kungayambitse zotsatira zingapo zomwe zimakhudza maso, chiwindi, impso ndi minofu.

Izi zikuwonetseredwa ndi ofufuza aku Britain omwe adasanthula zolemba za odwala opitilira 2 miliyoni, 16% mwa omwe adalandirapo kale mankhwala ndi ma statins.

Malinga ndi zomwe zasonkhanitsidwa, kwa ogwiritsa ntchito 10 aliwonse, kutenga ma statins pazaka 000 kumalepheretsa 5 matenda amtima, ndi 271 kuchuluka kwa khansa ya esophageal.

Komabe, zimayambitsanso 307 milandu yowonjezera ya ng'ala, milandu ya 74 ya matenda a chiwindi, 39 milandu ya myopathy ndi zina 23 zowonjezera kapena zovuta zowonongeka kwa aimpso, kachiwiri kwa 10 aliwonse omwe amagwiritsa ntchito mankhwalawa pazaka 000.

Zotsatirazi zinkawonekera kawirikawiri mwa amuna monga momwe zimakhalira akazi, kupatulapo myopathy - kapena kuchepa kwa minofu - zomwe zinakhudza pafupifupi kuwirikiza kawiri kwa amuna kuposa akazi.

Ndipo ngati zotsatirazi zidachitika zaka zonse za 5 zomwe odwala adatsatiridwa, makamaka panthawi ya 1^re chaka cha mankhwala anali kwambiri pafupipafupi.

Izi zikugwira ntchito pamitundu yonse ya ma statins omwe amagwiritsidwa ntchito pofufuza, mwachitsanzo, simvastatin (yomwe idaperekedwa kwa opitilira 70%), atorvastatin (22%), pravastatin (3,6%), rosuvastatin (1,9%) ndi fluvastatin (1,4). , XNUMX%).

Komabe, fluvastatin idayambitsa zovuta zachiwindi poyerekeza ndi magulu ena a ma statins.

Malinga ndi ochita kafukufuku, kafukufukuyu ndi amodzi mwa ochepa omwe amayesa kuchuluka kwa zotsatira zoyipa za kumwa ma statins - ambiri kuyerekeza zotsatira za izi pakuchepetsa chiopsezo cha mtima ndi placebo.

Komanso, amakhulupirira kuti mavuto omwe awonedwa sayenera kuphimba kuchepa kwa 24% kwa matenda amtima omwe kumwa mankhwala osokoneza bongo kwapereka, mkati mwa phunziroli.

Kumvetsera odwala kwambiri

Poganizira za zotsatira zomwe zalembedwa mu phunziroli, ochita kafukufuku amalimbikitsa kuti madokotala azitsatira odwala awo mosamala kwambiri kuti azindikire mwamsanga zotsatirapo zomwe zingachitike, kusintha kapena kusiya mankhwala awo, ngati kuli kofunikira.

Awanso ndi malingaliro a katswiri wa zamtima Paul Poirier, mkulu wa pulogalamu yopewa komanso kukonzanso mtima ku Institut de cardiologie et de pneumologie de Québec.

"Kafukufukuyu amatipatsa ziwerengero zenizeni zokhudzana ndi zochitika zowopsa, ndipo ndizowopsa," adatero. Komanso, kuchipatala, wodwala akalandira ma statins ali ndi vuto la muscular dystrophy kapena chiwindi, mankhwalawa amasiya. “

Chiwopsezo chachikulu chodwala ng'ala chimadabwitsa Paul Poirier. "Zidziwitso izi ndi zatsopano ndipo sizochepa chifukwa zimakhudza okalamba omwe akudwala kale, zomwe zimakhala ndi chiopsezo chowonjezera vuto lina," akupitiriza.

Malinga ndi dokotala wamtima, zotsatira zake ndi chenjezo kwa mayiko omwe akungoganiza zopanga ma statins popanda kulembedwa ndi dokotala.

"N'zoonekeratu kuti kugwiritsa ntchito ma statins kumafuna kuyang'anitsitsa ndipo kumafuna kuti odwala azidziwitsidwa mokwanira za zotsatirapo zake," akuwonjezera motero katswiri wamtima.

Koma kuposa pamenepo, kafukufuku waku UK amakhala ngati chikumbutso kwa madokotala omwe amachiritsa odwala awo ndi ma statins.

"Statin ndi mankhwala omwe amakhala ndi zoopsa ndipo tiyenera kutsatira odwala kwambiri. Koposa zonse, tiyenera kumvera ndi kukhulupirira wodwala yemwe akudandaula za zizindikiro, ngakhale izi sizinalembedwe m'mabuku asayansi: wodwala si chiwerengero kapena pafupifupi ndipo ayenera kuthandizidwa m'njira yapadera ", akumaliza motero D.^r Mtengo wa peyala.

Martin LaSalle - PasseportSanté.net

1. Hippisley-Cox J, Et alZotsatira zosayembekezereka za ma statins mwa amuna ndi akazi ku England ndi Wales: kafukufuku wamagulu a anthu pogwiritsa ntchito nkhokwe ya QResearch, British Medical Journal, lofalitsidwa pa intaneti 20 May 2010,; 340: c2197.

2. Rosenberg H, Allard D, Prudence amakakamiza: kugwiritsa ntchito ma statins mwa amayi, Action for the chitetezo cha thanzi la amayi, June 2007.