Acromegaly ndi matenda omwe amayamba chifukwa cha kuchuluka kwa timadzi tating'onoting'ono (yomwe timatchedwanso somatotropic hormone kapena GH for Growth Hormon). Izi zimabweretsa kusintha kwa mawonekedwe a nkhope, kuwonjezeka kwa kukula kwa manja ndi mapazi komanso ziwalo zambiri, zomwe zimayambitsa zizindikiro zazikulu ndi zizindikiro za matendawa.

Ndizovuta, zomwe zimakhudza pafupifupi 60 mpaka 70 mwa anthu miliyoni, zomwe zimayimira milandu 3 mpaka 5 pa anthu miliyoni pachaka.

Kwa akuluakulu, nthawi zambiri amapezeka pakati pa zaka za 30 ndi 40. Asanayambe kutha msinkhu, kuwonjezeka kwa GH kumayambitsa gigantism kapena giganto-acromegaly.

Choyambitsa chachikulu cha acromegaly ndi chotupa chosaopsa (chopanda khansa) cha pituitary gland, gland (yotchedwanso pituitary gland), yomwe ili mu ubongo ndipo nthawi zambiri imatulutsa mahomoni angapo kuphatikizapo GH.