Matenda a Alzheimer. Makhalidwe awiri a umunthu amathandizira kudwala matenda a maganizo. Kuopsa kwanu ndi kotani?

Alzheimer's imawononga ubongo mosasinthika, imachotsa kukumbukira komanso kukhala ndi moyo wodziyimira pawokha. Ngakhale kuti anthu mamiliyoni makumi ambiri akulimbana nawo kale (ndipo chiwerengero chikukula mofulumira), matendawa amabisabe zinsinsi. Sizikudziwikabe chomwe chimayambitsa ndondomeko yowonongeka mu dongosolo la mitsempha. Komabe, asayansi anapeza njira ina. Zikuwonekeratu kuti mikhalidwe iwiri ya umunthu ingakomere kukula kwa Alzheimer's. Kodi kwenikweni anapeza chiyani?

1. Alzheimer's ndi matenda a muubongo osasinthika omwe amawononga pang'onopang'ono kukumbukira ndi kulingalira. - Zimafika poti munthu sakumbukira zomwe adachita kale kapena zomwe zidachitika m'mbuyomu. Pali chisokonezo chonse ndi kusowa thandizo - akutero katswiri wa minyewa Dr. Milczarek
2. Kuchuluka kwa zolembera za amyloid ndi tau muubongo zimadziwika kuti zimalumikizidwa ndi matenda a Alzheimer's ndi dementias yofananira.
3. Kafukufuku wopangidwa ndi asayansi awonetsa kuti mikhalidwe iwiri ya umunthu imatha kulumikizidwa ndi kukula kwa Alzheimer's, makamaka ndi kuyika kwa zinthu izi muubongo.
4. Zambiri zofunikira zitha kupezeka patsamba lofikira la Onet.

Matenda a Alzheimer's - Zomwe Zimakuchitikirani Ndi Chifukwa Chiyani

Matenda a Alzheimer ndi matenda osachiritsika a ubongo omwe amawononga minyewa (ubongo umachepa pang'onopang'ono), komanso kukumbukira, luso loganiza komanso, pomaliza, kuthekera kochita zinthu zosavuta. Matenda a Alzheimer's akupita patsogolo, zomwe zikutanthauza kuti zizindikiro zimayamba pang'onopang'ono kwa zaka zambiri, zomwe zimayambitsa mavuto ambiri.

Pakupita patsogolo, wodwalayo sangathenso kuchita ntchito za tsiku ndi tsiku - sangathe kuvala, kudya, kusamba, amadalira kwambiri chisamaliro cha ena. - Zimafika poti munthu sakumbukira zomwe adachita kale kapena zomwe zidachitika m'mbuyomu. Pali chisokonezo chonse komanso kusowa thandizo - adatero katswiri wa zamaganizo Dr. Olga Milczarek wochokera ku SCM Clinic ku Krakow poyankhulana ndi MedTvoiLokona. (Kuyankhulana Kwathunthu: Mu matenda a Alzheimer's, ubongo umachepa ndikuchepa. Chifukwa chiyani? akufotokoza motero katswiri wa mitsempha).

Zimadziwika kuti chifukwa cha matenda a Alzheimer's ndi kumanga-mmwamba mitundu iwiri ya mapuloteni mu ubongo: otchedwa beta-amyloid; ndi mapuloteni a tau kutenga malo a mitsempha ya mitsempha. - Malowa amakhala granular, m'madzi, spongy, amagwira ntchito pang'onopang'ono ndipo pamapeto pake amatha - akufotokoza Dr. Milczarek. Malo omwe mankhwalawa amawunjikana amatsimikizira zizindikiro zomwe zidzawonekere mwa wodwala wopatsidwa.

Tsoka ilo, sizikudziwikabe chomwe chimayambitsa njira yowonongayi. Zikutheka kuti zimakhudzidwa ndi kuphatikiza kwa majini, chilengedwe komanso moyo. Kufunika kwa chilichonse mwa izi pakuwonjezera kapena kuchepetsa chiopsezo chokhala ndi matendawa kumatha kusiyana pakati pa anthu. Pankhani imeneyi, asayansi anapeza chinthu chochititsa chidwi kwambiri. Zikuwonekeratu kuti mikhalidwe iwiri ya z ingakomere kapena kuchepetsa chiopsezo cha kusintha kowononga mu ubongo. Zotsatira za kafukufukuyu zidasindikizidwa mu nyuzipepala ya sayansi ya Biological Psychiatry.

Makhalidwe aumunthu omwe amapanga Big Five. Akutanthauza chiyani?

Tisanafotokoze zomwe zili, tiyenera kutchula zomwe zimatchedwa Big Five, chitsanzo cha umunthu chomwe chili ndi zinthu zisanu zazikulu. Asayansi anenapo za iwo.

1. Werenganinso: Mlingo wa shuga ndi cholesterol komanso chiopsezo cha Alzheimer's. “Anthu sadziwa”

Makhalidwe amenewa amadziwika kuti amakula adakali aang'ono ndipo, malinga ndi akatswiri a zamaganizo, "amakhudza kwambiri zotsatira za moyo". The Big Five ili ndi:

Kuyanjana - malingaliro ku dziko lachitukuko. Makhalidwe amenewa amafotokoza za munthu amene ali wabwino kwa ena, waulemu, wachifundo, wokhulupirira, woona mtima, wogwirizana, kuyesetsa kupewa mikangano.

Kutsegula - limafotokoza munthu yemwe ali ndi chidwi chofuna kudziwa za dziko lapansi, wotseguka ku zochitika zatsopano / malingaliro otuluka kuchokera kudziko lakunja ndi lamkati.

Kuthamanga Kwambiri - akulemba munthu yemwe akufunafuna chisangalalo, ali wokangalika, wochezeka kwambiri, wofunitsitsa kusewera

Kusamala - limafotokoza munthu yemwe ali ndi udindo, wokakamizika, wosamala, wokonda zolinga komanso watsatanetsatane, komanso wosamala. Pamene kuli kwakuti kuchulukira kwa mkhalidwe umenewu kungayambitse kutengeka ndi ntchito, wofooka amatanthauza kusalabadira kwambiri kukwaniritsa ntchito zake ndi kuchita zinthu mwachisawawa.

Neuroticism - kumatanthauza chizolowezi chokhala ndi malingaliro oyipa, monga nkhawa, mkwiyo, chisoni. Anthu omwe ali ndi chikhalidwe ichi amakonda kupsinjika, amakumana ndi zovuta zonse, ndipo zochitika za moyo wamba zimatha kuwoneka zowopseza komanso zokhumudwitsa kwa iwo. Amavutika kuti abwererenso m'maganizo, ndipo nthawi zambiri zimatenga nthawi yayitali.

Ofufuzawa adasanthula ziwiri zomwe zidapangitsa kuti pakhale mfundo imodzi. Zimatanthawuza mikhalidwe iwiri yomaliza ya Big Five: chikumbumtima ndi neuroticism.

Makhalidwe awiri a Big Five ndi zotsatira zake pakukula kwa Alzheimer's. Maphunziro awiri, mfundo imodzi

Anthu opitilira 3 adatenga nawo gawo pa kafukufukuyu. anthu. Choyamba, tidasanthula deta kuchokera kwa anthu omwe akutenga nawo gawo mu Baltimore Longitudinal Study of Aging (BLSA) - kafukufuku wotalika kwambiri ku America wokhudza ukalamba wa anthu.

Kuti adziwe zomwe zili mu Big Five, otenga nawo mbali adalemba mafunso omwe ali ndi zinthu za 240. Pasanathe chaka chimodzi chomaliza chikalatachi, otenga nawo mbali adafufuzidwa kuti alipo (kapena kusakhalapo) kwa zolembera za amyloid ndi tau muubongo wawo. Izi zinatheka ndi PET (positron emission tomography) - kuyesa kosasokoneza kujambula.

Ntchito yachiwiri inali meta-kuwunika kwa maphunziro 12 omwe amafufuza ubale pakati pa matenda a Alzheimer's pathology ndi umunthu.

I Kafukufuku wozikidwa ndi BLSA komanso kusanthula kwa meta kudapangitsa kuti mfundo yomweyo: mgwirizano wamphamvu kwambiri pakati pa chiopsezo chokhala ndi dementia unali wogwirizana ndi mikhalidwe iwiri: neuroticism ndi chikumbumtima. Anthu omwe ali ndi vuto lalikulu la neuroticism kapena chikumbumtima chochepa amatha kukhala ndi zolembera za amyloid ndi tangles. Anthu omwe ali ndi chidziwitso chochuluka kapena otsika kwambiri a neuroticism anali osatheka kuti akumane nazo.

1. Pezani zambiri: Achinyamata amakhudzidwanso ndi dementia ndi matenda a Alzheimer. Kodi kuzindikira? Zizindikiro zachilendo

Wina angafunse ngati ubalewu umayamba ndi mulingo wina wa mphamvu zonse ziwiri. Dr. Antonio Terracciano, wa ku Florida State University Department of Geriatrics, ali ndi yankho: Maulalo awa akuwoneka ngati ali pamzere, wopanda malire […], ndipo alibe mulingo wachindunji womwe umayambitsa kukana kapena kutengeka.

Phunziro lomwe tatchulalo linali lachiwonetsero, kotero silinapereke yankho ku funso la zomwe zimapangidwira zomwe zimayambitsa zochitika zomwe zapezeka. Ngakhale kuti kafukufuku wochuluka akufunika pano, asayansi ali ndi malingaliro angapo.

Malinga ndi Dr. Claire Sexton, mkulu wa mapulogalamu ofufuza ndi thandizo ku Alzheimer's Association (osachita nawo kafukufuku), "njira imodzi yomwe ingatheke ndiyo kutupa kwa umunthu ndi chitukuko cha Alzheimer's biomarkers." "Moyo ndi njira ina yotheka," akutero Dr. Sexton. - Mwachitsanzo, anthu omwe ali ndi chidziwitso chapamwamba asonyezedwa kuti amakhala ndi moyo wathanzi (mwa kuchita masewera olimbitsa thupi, kusuta fodya, kugona, kulimbikitsa chidziwitso, etc.) kusiyana ndi omwe ali ndi chikumbumtima chochepa.

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