Alzheimer's - izi zitha kukhala zizindikilo zoyamba kale matendawa asanachitike. Phunziro latsopano

Osati mavuto a kukumbukira okha. Zizindikiro zoyamba za matenda a Alzheimer zingawonekere kale kwambiri. “Zotsatira za cholandirira muubongo zokhudzana ndi chisonkhezero ndi malingaliro zimadzetsa imfa ya ma neuron ndi kusokonekera kwa dongosolo la synaptic mwa anthu omwe ali ndi matenda a Alzheimer,” akutero asayansi a ku Indiana University School of Medicine m’magazini ya Molecular Psychiatry.

1. Ngakhale kuti matenda a Alzheimer's amagwirizana ndi okalamba, asayansi ochulukirapo akuwonetsa kuti zizindikiro zake zoyambirira zimatha kuwoneka pafupifupi pafupifupi makumi anayi.
2. Tsopano zapezedwa kuti kale kwambiri mavuto a kukumbukira asanakhalepo, odwala amakhala ndi zizindikiro monga mphwayi ndi kukwiya.
3. Zambiri zitha kupezeka patsamba lofikira la Onet

Matenda a Alzheimer's - Ndi Magawo Ati Mu Ubongo Amakhudza?

Pakufufuza kwawo, asayansi adayang'ana kwambiri pa nucleus accumbens (imodzi mwa basal ganglia) yomwe ili mu striatum. Derali ndi gawo la dongosolo la mphotho ndipo limakhudza chilimbikitso.

- Pakhala pali chidwi chochepa mu nucleus accumbens monga dongosolo lokhudzana ndi matenda a Alzheimer's. Amaphunziridwa makamaka kuti amvetsetse njira zolimbikitsira komanso zamalingaliro. Maphunziro am'mbuyomu, komabe, adapeza kuti kuchuluka kwa nucleus accumbens, komanso madera a cortical ndi hippocampus, kumachepetsedwa mwa odwala a Alzheimer's, olemba akutero.

Ngakhale kuti chidziwitso chisanayambike, anthu ambiri omwe ali ndi matenda a Alzheimer amasinthasintha maganizo, ndipo nthawi zambiri amakhala ndi zizindikiro za kuvutika maganizo.

Kodi mukufuna kudziwa chifukwa cha malaise anu? Chitani Mood Swings - phukusi la mayeso omwe amawunika zomwe zimayambitsa kusayenda bwino komwe kulipo mu mtundu wokhala ndi zitsanzo zamagazi am'nyumba, zomwe zimathandizira kwambiri kuzindikira, makamaka kwa okalamba omwe ali ndi vuto lofikira kuchipatala.

Mphwayi ndi kukwiya - zizindikiro zoyamba za Alzheimer's?

- Komabe, zizindikiro za neuropsychiatric, monga mphwayi ndi kukwiya, zimachitika kale kusiyana ndi vuto la kukumbukira, choncho n'zovuta kuyankha panthawi yake.. Choncho, tiyenera kumvetsetsa chifukwa chake zizindikirozi zimawonekera komanso momwe zimagwirizanirana ndi kuperewera kwa chidziwitso, akutsindika mlembi wa phunziroli, Dr. Yao-Ying Ma.

Pakukumbukira ndi kukhazikika, gwiritsani ntchito Lecithin 1200mg pafupipafupi - kukumbukira kwa MEMO ndi kukhazikika, zomwe mungagule pamtengo wotsatsa ku Msika wa Medonet.

Pophunzira za mtundu wa matenda a Alzheimer's, asayansi adazindikira ma CP-AMPA (calcium ion permeable) zolandilira mu nucleus accumbens zomwe zimakhudzidwa ndi kufalitsa mwachangu kwa synaptic. Ma receptor awa, omwe nthawi zambiri sapezeka mbali iyi ya ubongo, amalola ayoni a calcium kulowa m'maselo a mitsempha. Kashiamu wochuluka, nawonso, amabweretsa kusokonezeka kwa ntchito za synaptic ndipo kumayambitsa kusintha kwapakati pa cell komwe kungayambitse kufa kwa neuronal.

Kutayika kumeneku kwa ma synaptic kumabweretsa zovuta zolimbikitsa. Chifukwa chake, kutsata ndi kutsekereza zolandilira za CP-AMPA zitha kuchedwetsa kukula kwa matenda a Alzheimer's.

- Ngati titha kuchedwetsa kusintha kwa matenda m'madera omwe akhudzidwa, mwachitsanzo mu nucleus accumbens, zikhoza kuthandizira kuchedwa kwa zilonda m'madera ena - ndemanga Dr. Ma.