Matenda osapatsiranawa amadziwika ndi mapangidwe a mapuloteni omwe amasintha kugwira ntchito kwa ziwalo. Nthawi zambiri amapita patsogolo kwambiri ndipo amatha kukhudza ziwalo zonse. Sitikudziwa bwinobwino chiwerengero cha anthu amene akhudzidwa ndi matendawa ku France, koma akuti amakhudza munthu mmodzi pa anthu 1 alionse. (100) Chaka chilichonse ku France, pafupifupi 000 matenda atsopano a AL amyloidosis amapezeka. wochepa osowa mawonekedwe a matenda.

Ma depositi a Amyloidosis amatha kuwoneka pafupifupi pafupifupi minofu ndi chiwalo chilichonse m'thupi. Amyloidosis nthawi zambiri imayamba kukhala yovuta kwambiri powononga pang'onopang'ono ziwalo zomwe zakhudzidwa: impso, mtima, m'mimba ndi chiwindi ndi ziwalo zomwe zimakhudzidwa kwambiri. Koma amyloidosis imathanso kukhudza mafupa, mafupa, khungu, maso, lilime ...

Chifukwa chake, mitundu yosiyanasiyana yazizindikiro ndi yotakata kwambiri: kusapeza bwino komanso kupuma movutikira pamene mtima umakhudzidwa, edema ya miyendo pokhudzana ndi impso, kutsika kwa minofu pamene mitsempha yotumphukira imakhudzidwa, kutsekula m'mimba / kudzimbidwa komanso kutsekeka. impso. Matenda a m'mimba, ndi zina zotero. Zizindikiro zazikulu monga kupuma movutikira, kutsekula m'mimba ndi kutuluka magazi ziyenera kukhala tcheru ndikuyambitsa kuyezetsa amyloidosis.

Amyloidosis imayamba chifukwa cha kusintha kwa mamolekyu a mapuloteni, kuwapangitsa kuti asasungunuke m'thupi. Puloteniyo imapanga ma deposits a molekyulu: chinthu cha amyloid. Ndizolondola kunena za amyloidosis kusiyana ndi amyloidosis, chifukwa ngakhale kuti matendawa ali ndi chifukwa chomwecho, mawu ake ndi osiyana kwambiri. M'malo mwake, pafupifupi mapuloteni makumi awiri ali ndi udindo wamitundu yambiri. Komabe, pali mitundu itatu ya amyloidosis: AL (immunoglobulinic), AA (yotupa) ndi ATTR (transthyretin).

• AL amyloidosis imachokera ku kuchulukitsidwa kwa maselo ena oyera a magazi (maselo a plasma). Amatulutsa ma antibodies (immunoglobulins) omwe amaphatikizana ndikupanga ma depositi.
• AA amyloidosis imachitika pamene kutupa kosatha kumayambitsa kupanga kwakukulu kwa mapuloteni a SAA omwe amapanga amyloidosis mu minofu.
• Puloteni ya transthyretin imakhudzidwa ndi ATTR amyloidosis. Mtundu uwu wa matendawa ndi chibadwa. Makolo okhudzidwa ali ndi chiopsezo cha 50% chopatsira mwana wawo kusintha.

Amyloidosis si opatsirana. Deta ya Epidemiological ikuwonetseratu kuti chiopsezo chimawonjezeka ndi zaka (amyloidosis nthawi zambiri imapezeka pafupifupi zaka 60-70). Anthu omwe ali ndi matenda opatsirana kapena otupa, komanso omwe adalandira dialysis kwa nthawi yayitali, amakhala pachiwopsezo chachikulu. Monga mitundu ina ya amyloidosis, monga ATTR amyloidosis, imagwirizanitsidwa ndi kusintha kwachibadwa, mabanja omwe munthu mmodzi kapena angapo akhudzidwa ayenera kukhala ndi kuyang'anitsitsa mwapadera.

Mpaka pano, palibe njira zopewera kulimbana ndi amyloidosis. Mankhwalawa onse amakhala ndi kuchepetsa kupanga kwa puloteni wapoizoni yemwe amayikidwa ndikuphatikizana mu minofu, koma amasiyana malinga ndi mtundu wa amyloidosis:

• ndi chemotherapy pankhani ya AL amyloidosis. Mankhwala omwe amagwiritsidwa ntchito pochiza akuwonetsa ” wachangu kwenikweni », Ikutsimikizira National Society of Internal Medicine (SNFMI), pomwe ikunena kuti kugunda kwa mtima kumakhalabe koopsa.
• kugwiritsa ntchito mankhwala amphamvu oletsa kutupa kuti athane ndi kutupa komwe kunayambitsa AA amyloidosis.
• Kwa ATTR amyloidosis, kumuika kungakhale kofunikira kuti m'malo mwa chiwindi chodzaza ndi mapuloteni oopsa.

French Association motsutsana ndi Amyloidosis imafalitsa zambiri za matendawa ndi chithandizo chake, chomwe chimapangidwira odwala ndi achibale awo.