Anaplastic oligoastrocytoma, kapena anaplastic astrocytoma, ndi chotupa choopsa cha muubongo. Ndi glioma, ndiye kuti chotupa chochokera ku minofu yamanjenje, muubongo kapena mumsana. Bungwe la World Health Organisation limayika ma gliomas kuchokera ku I mpaka IV, kutengera momwe amapangidwira komanso kuchuluka kwa zilonda. Anaplastic astrocytomas imayimira giredi III, pakati pa giredi I ndi II amaonedwa kuti ndi abwino komanso glioblastomas (giredi IV). Anaplastic astrocytoma ikhoza kukhala vuto la chotupa choyipa cha giredi II kapena kukula chokha. Ali ndi chizoloŵezi champhamvu chopita patsogolo kufika pa glioblastoma (giredi IV) ndipo moyo umakhala pafupifupi zaka ziwiri kapena zitatu, ngakhale amathandizidwa ndi opaleshoni ndi radiotherapy / chemotherapy. Anaplastic astrocytomas ndi glioblastomas zimakhudza 5 mpaka 8 mwa anthu 100 mwa anthu wamba. (000)

Zizindikiro zambiri za anaplastic oligoastrocytoma zimabwera chifukwa cha kuchuluka kwamphamvu muubongo, komwe kumachitika chifukwa cha chotupacho kapena chifukwa cha kuchuluka kwamadzimadzi muubongo komwe kumayambitsa. Zizindikiro zimasiyanasiyana malinga ndi malo enieni komanso kukula kwa chotupacho:

• Kuwonongeka kwa kukumbukira, kusintha kwa umunthu ndi hemiplegia pamene chotupacho chikukula kutsogolo kwa lobe;
• Kukomoka, kusokonezeka kwa kukumbukira, kulumikizana ndi kulankhula mukakhala mu lobe yanthawi;
• Kusokonezeka kwa magalimoto ndi kusokonezeka kwamalingaliro (kuyabwa ndi kuyaka) pamene kuli parietal lobe;
• Kusokonezeka kowoneka pamene chotupacho chimakhudza lobe ya occipital.

Chifukwa chenicheni cha anaplastic astrocytoma sichidziwikabe, koma ochita kafukufuku amakhulupirira kuti zimachokera ku kuphatikiza kwa majini ndi zinthu zachilengedwe zomwe zimayambitsa matendawa.

Anaplastic oligoastrocytoma ndi yofala kwambiri mwa amuna kuposa akazi ndipo nthawi zambiri imapezeka pakati pa zaka zapakati pa 30 ndi 50. Komabe, ziyenera kudziwidwa kuti matendawa amatha kugwira ana, nthawi zambiri pakati pa 5 ndi 9 zaka. Anaplastic astrocytomas ndi multiform glioblastomas (magiredi III ndi IV) amayimira pafupifupi 10% ya zotupa zaubwana mkatikati mwa mitsempha yapakati (80% ya zotupazi zimakhala giredi I kapena II). (1)

Matenda amtundu wa neurofibromatosis mtundu Woyamba (matenda a Recklinghausen), Li-Fraumeni syndrome, ndi Bourneville tuberous sclerosis amawonjezera chiopsezo chokhala ndi anaplastic astrocytoma.

Monga momwe zimakhalira ndi khansa zambiri, zinthu zachilengedwe monga cheza cha ultraviolet, kuwala kwa ionizing ndi mankhwala ena, komanso zakudya zopanda thanzi komanso kupsinjika maganizo zimaonedwa kuti ndizoopsa.

Chithandizo cha anaplastic oligoastrocytoma chimadalira makamaka momwe wodwalayo alili, malo a chotupacho komanso kuthamanga kwake. Zimaphatikizapo opaleshoni, radiotherapy ndi chemotherapy, payekha kapena kuphatikiza. Chinthu choyamba ndikuchita opaleshoni kuchotsa gawo lalikulu la chotupa momwe ndingathere (resection), koma izi sizingatheke chifukwa cha magawo omwe tawatchula pamwambapa. Pambuyo pa opaleshoni, chithandizo cha radiation komanso mwina chemotherapy chimagwiritsidwa ntchito kuyesa kuchotsa zotsalira za chotupa, mwachitsanzo ngati maselo owopsa afalikira mu minofu yaubongo.

Matendawa amayenderana ndi thanzi la wodwalayo, momwe chotupacho chilili, komanso momwe thupi limayankhira chithandizo chamankhwala ndi ma radiotherapy. Anaplastic astrocytoma ali ndi chizolowezi champhamvu kupita patsogolo ku glioblastoma pafupifupi zaka ziwiri. Ndi chithandizo chokhazikika, nthawi yopulumuka yapakatikati kwa anthu omwe ali ndi anaplastic astrocytoma ndi zaka ziwiri kapena zitatu, zomwe zikutanthauza kuti theka la iwo adzafa nthawiyi isanafike. (2)