Michael Greger, MD March 27, 2014
N’chifukwa chiyani kudya masamba pafupipafupi kumawoneka kuti kukuchepetsa mwayi woti munthu adwale matenda ovutika maganizo ndi theka?
Mu 2012, ofufuza adapeza kuti kuchotsa nyama kumapangitsa kuti azikhala bwino kwa milungu iwiri. Ofufuza amatsutsa asidi arachidonic, omwe amapezeka makamaka nkhuku ndi mazira, chifukwa cha zotsatira zoipa pa thanzi la maganizo. Acid iyi imayambitsa kukula kwa kutupa kwa ubongo.
Koma kusintha kwa chikhalidwe chochokera ku zomera kungakhalenso chifukwa cha phytonutrients yomwe imapezeka muzomera, zomwe zimadutsa chotchinga cha magazi m'mitu yathu. Ndemanga yaposachedwa m'magazini ya Nutritional Neuroscience ikusonyeza kuti kudya zipatso ndi ndiwo zamasamba kungaimirire mankhwala osawononga zachilengedwe komanso otsika mtengo komanso kupewa matenda a ubongo. Koma bwanji?
Kuti timvetsetse kafukufuku waposachedwa, tifunika kudziwa zomwe zimayambitsa kupsinjika maganizo, zomwe zimatchedwa monoamine theory of depression. Lingaliro ili ndikuti kukhumudwa kumatha kubwera chifukwa cha kusalinganika kwamankhwala muubongo.
Njira imodzi imene minyewa mabiliyoni ambiri muubongo wathu ingalankhulire wina ndi mzake ndiyo kuyanjanitsa kwa zizindikiro za mankhwala zotchedwa neurotransmitters. Ma cell a minyewa awiriwa samakhudza kwenikweni - pali kusiyana pakati pawo. Kuti atseke kusiyana kumeneku, pamene mitsempha imodzi ikufuna kuwotcha wina, imatulutsa mankhwala mumpata umenewo, kuphatikizapo monoamines atatu: serotonin, dopamine, ndi norepinephrine. Ma neurotransmitter awa amasambira kupita ku minyewa ina kuti atenge chidwi chake. Mtsempha woyamba umawayamwanso kuti agwiritsenso ntchito nthawi ina akafuna kuyankhula. Komanso nthawi zonse amapanga monoamines ndi ma enzymes, monoamine oxidase, amawatenga nthawi zonse ndikusunga kuchuluka koyenera.
Kodi cocaine imagwira ntchito bwanji? Zimagwira ntchito ngati monoamine reuptake inhibitor. Zimalepheretsa minyewa yoyamba, ndikuyilepheretsa kuyamwa mankhwala atatuwa omwe amakakamizika kugunda pamapewa nthawi zonse ndikuwonetsa ku selo lotsatira. Amphetamine amagwira ntchito mofananamo komanso amawonjezera kutulutsidwa kwa monoamines. Ecstasy imagwira ntchito ngati amphetamine, koma imayambitsa kutulutsa kwakukulu kwa serotonin.
Pakapita nthawi, msempha wotsatira unganene kuti, “Zakwanira! ndikupondereza ma receptor anu kuti muchepetse voliyumu. Izi zikufanana ndi zotsekera m'makutu. Choncho tiyenera kumwa mankhwala ochulukirachulukira kuti tichite zomwezo, ndipo tikapanda kuwapeza, titha kumva kuti ndife owopsa chifukwa kufalikira kwabwinobwino sikudutsa.
Ma antidepressants amaganiziridwa kuti ali ndi njira zofanana. Anthu omwe akuvutika ndi kupsinjika maganizo ali ndi kuchuluka kwa monoamine oxidase mu ubongo. Ndi enzyme yomwe imaphwanya ma neurotransmitters. Miyezo yathu ya neurotransmitter ikatsika, timakhumudwa (kapena lingalirolo likupita).
Motero, mitundu ingapo ya mankhwala yapangidwa. Tricyclic antidepressants amalepheretsa kutengekanso kwa norepinephrine ndi dopamine. Ndiye panali SSRIs (Selective Serotonin Reuptake Inhibitors), monga Prozac. Tsopano tikudziwa zomwe zikutanthauza - amangoletsa kuyambiranso kwa serotonin. Palinso mankhwala omwe amangolepheretsa kutengekanso kwa norepinephrine, kapena kuletsa kubwezeretsanso kwa dopamine, kapena kuphatikiza zonse ziwiri. Koma ngati vuto ndi monoamine oxidase wambiri, bwanji osangotsekereza enzyme? Pangani monoamine oxidase inhibitors. Anatero, koma monoamine oxidase inhibitors amaonedwa kuti ndi mankhwala omwe ali ndi mbiri yoipa chifukwa cha zotsatira zoyipa zomwe zingathe kupha.
Tsopano titha kulankhula za chiphunzitso chaposachedwa kwambiri cha chifukwa chake zipatso ndi ndiwo zamasamba zimatha kusintha malingaliro athu. Zoletsa kuvutika maganizo zimapezeka muzomera zosiyanasiyana. Zonunkhira monga cloves, oregano, sinamoni, nutmeg zimalepheretsa monoamine oxidase, koma anthu samadya zonunkhira zokwanira kuti athetse ubongo wawo. Fodya ali ndi zotsatira zofanana, ndipo izi zikhoza kukhala chimodzi mwa zifukwa zomwe zimachititsa kuti munthu azisangalala akamasuta fodya.
Chabwino, koma bwanji ngati sitikufuna kusinthanitsa malingaliro oipa a khansa ya m'mapapo? Monoamine oxidase inhibitor yomwe imapezeka mu maapulo, zipatso, mphesa, kabichi, anyezi, ndi tiyi wobiriwira imatha kukhudza ubongo wathu mokwanira kuti tisangalale, ndipo zingathandize kufotokoza chifukwa chake omwe amakonda zakudya zochokera ku zomera amakhala ndi maganizo apamwamba. thanzi labwino.
Mankhwala awo ena achilengedwe a matenda amisala amatha kupangira safironi ndi lavenda.