Hypogammaglobulonemia ndi kuchepa kwa gamma-globulins kapena ma immunoglobulins, zinthu zomwe zimakhala ndi gawo lofunikira mu chitetezo chamthupi. Kusokonezeka kwachilengedwe kumeneku kumatha kukhala chifukwa chomwa mankhwala enaake kapena ma pathologies osiyanasiyana, ena omwe amafunikira kuwunika mwachangu. 

Hypogammaglobulinemia imatanthauzidwa ndi mulingo wa gamma-globulin wochepera 6 g/l pa plasma protein electrophoresis (EPP). 

Ma Gamma globulins, omwe amatchedwanso ma immunoglobulins, ndi zinthu zopangidwa ndi maselo amwazi. Iwo ali ndi ntchito yofunika kwambiri pa chitetezo cha thupi. Hypogammaglobumonemia imabweretsa kuchepa kwambiri kapena kuchepera kwa chitetezo chamthupi. Ndizosowa.

Kufufuza komwe kumapangitsa kuti munthu adziwe za gamma-globulins, mwa zina, ndi electrophoresis ya mapuloteni a seramu kapena mapuloteni a plasma. Amachitidwa ngati akukayikira matenda ena kapena kutsatira zotsatira zachilendo panthawi yofufuza koyamba. 

Kufufuza kumeneku kumaperekedwa ngati akukayikira kuti ali ndi vuto la chitetezo chamthupi pamaso pa matenda obwerezabwereza, makamaka a ENT ndi bronchopulmonary sphere kapena kuwonongeka kwa chikhalidwe, ngati mukukayikira kuti muli ndi myeloma yambiri (zizindikiro: kupweteka kwa mafupa, kuchepa kwa magazi m'thupi), matenda pafupipafupi…). 

Kuyezetsa kumeneku kungagwiritsidwenso ntchito potsatira zotsatira zachilendo zosonyeza kuwonjezeka kapena kuchepa kwa mapuloteni a seramu, mapuloteni ochuluka a mkodzo, calcium yambiri m'magazi, kusokonezeka kwa chiwerengero cha maselo ofiira a magazi kapena maselo oyera a magazi.

Electrophoresis ya mapuloteni a seramu ndikuwunika komwe kumapangitsa kuti athe kuyeza ma gamma globulins. 

Kuyesa kwa biology kwachizolowezi (chitsanzo chamagazi, nthawi zambiri kuchokera pachigongono) chimalola kuchulukira kwa magawo osiyanasiyana a mapuloteni a seramu (albumin, alpha1 ndi alpha2 globulins, beta1 ndi beta2 globulins, gamma globulin). 

Electrophoresis ya mapuloteni a seramu ndi kufufuza kosavuta komwe kumapangitsa kuti athe kuzindikira ndi kutenga nawo mbali pakuwunika kwa ma pathologies ambiri: ma syndromes otupa, khansa zina, matenda a thupi kapena zakudya.

Imawongolera mayeso owonjezera ofunikira (immunofixation ndi / kapena kuyesa kwa mapuloteni, kuwunika kwa hematological, kufufuza aimpso kapena kugaya chakudya).

Kupezeka kwa hypogammaglobulonemia kungakhale chifukwa cha kumwa mankhwala (oral corticosteroid therapy, immunosuppressants, anti-epileptics, chotupa chemotherapy, etc.) kapena matenda osiyanasiyana. 

Mayesero owonjezera amalola kuti munthu adziwe kuti ali ndi chifukwa cha mankhwala. 

Kuzindikira ma pathologies omwe ndi matenda adzidzidzi (light chain myeloma, lymphoma, chronic myeloid leukemia), mayeso atatu amachitika: kufufuza matenda a chotupa (lymphadenopathy, hepato-splenomegaly), kuzindikira kwa proteinuria ndi kuwerengera magazi.

Izi zikangodziwika kuti pali zifukwa zina za hypogammaglobulonemia: nephrotic syndrome, exudative enteropathies. Zomwe zimayambitsa matenda a exudative enteropathies zimatha kukhala matenda otupa, matenda a celiac komanso zotupa zolimba zam'mimba kapena ma lymphoid hemopathies monga lymphoma kapena primary amyloidosis (LA, light chain amyloidosis of immunoglobulins).

Nthawi zambiri, hypogammaglobulinemia imatha kuyambitsidwa ndi kuchepa kwa chitetezo chamthupi.

Kuperewera kwa zakudya m'thupi kapena Cushing's syndrome kungayambitsenso hypogammaglobulonemia.

Mayeso owonjezera amalola kuti azindikire matendawa (thoraco-abdominal-pelvic scanner, kuchuluka kwa magazi, kutupa, albuminemia, proteinuria ya maola 24, kutsimikiza kulemera kwa immunoglobulins ndi immunofixation ya magazi)

Chithandizo chimadalira chifukwa. 

Ikhoza kukhazikitsidwa ndi njira zothandizira anthu omwe akudwala hypogammaglobulinemia: katemera wotsutsa pneumococcal ndi katemera wina, antibiotic prophylaxis, m'malo mwa polyvalent immunoglobulins.