Serum protein electrophoresis ndi mayeso omwe amapangidwa kuchokera pakuyezetsa magazi komwe kumathandizira kuzindikira ndi kuyang'anira matenda ambiri monga monoclonal immunoglobulin, hypergammaglobulinemia komanso kawirikawiri hypogammaglobulinemia.

Serum protein electrophoresis (EPS) ndi mayeso azachipatala a biology. Cholinga chake ndikulekanitsa mapuloteni omwe amapezeka mumadzi am'magazi (seramu). "Mapuloteniwa amathandizira kwambiri kunyamula mamolekyu ambiri (mahomoni, lipids, mankhwala, ndi zina), komanso amathandizira kuti magazi asamayende bwino, chitetezo chamthupi chitetezeke komanso kuwongolera kuthamanga kwa magazi. Kupatukana kumeneku kupangitsa kuti zitheke kuzizindikira ndikuziwerengera ”, akutero Dr Sophie Lyon, katswiri wazachipatala.

Kusanthula kwa mapuloteni

Pambuyo poyezetsa magazi, mapuloteni amawunikidwa ndi kusamuka m'munda wamagetsi. "Kenako amasiyana malinga ndi mphamvu yawo yamagetsi ndi kulemera kwawo kwa maselo, zomwe zimapangitsa kuti athe kuzizindikira ndikuwona zolakwika." EPS idzalola kulekana kwa tizigawo ting'onoting'ono ta mapuloteni, mu kuchepa kwa liwiro la kusamuka kwawo: albumin (yomwe ndi mapuloteni akuluakulu a seramu, pamaso pa 60%), alpha 1-globulins, alpha 2-globulins, Beta 1 globulin, Beta 2 globulin ndi gammaglobulins. "Electrophoresis imapangitsa kuti zitheke kuzindikira matenda ena okhudzana ndi kusagwira bwino ntchito kwa chiwindi kapena impso, kusintha kwa chitetezo chamthupi, kukhala ndi zizindikiro zotupa kapena khansa zina".

Mikhalidwe yolembera EPS idafotokozedwa ndi Haute Autorité de Santé (HAS) mu Januwale 2017. Chifukwa chachikulu chomwe EPS imapangidwira ndikufufuza monoclonal immunoglobulin (monoclonal gammopathy, kapena dysglobulinemia). Izi zimasamuka nthawi zambiri kudera la gamma globulins ndipo nthawi zina kudera la beta-globulins kapena alpha2-globulins.

Ndi liti pamene muyenera kuchita PSE?

Muyenera kuchita EPS mukakhala patsogolo pa:

• Kuchuluka kwa mapuloteni ozungulira;
• Kuwonjezeka mosadziwika bwino kwa sedimentation rate (VS);
• Matenda obwerezabwereza, makamaka mabakiteriya (fufuzani kuchepa kwa chitetezo cha mthupi komwe kumayambitsa hypogammaglobulinemia);
• Mawonetseredwe azachipatala kapena achilengedwe (hypercalcemia, mwachitsanzo) akuwonetsa kuchitika kwa myeloma kapena matenda amagazi;
• A kukayikira kutupa syndrome;
• Mwina matenda enaake;
• Kufufuza kulikonse kwa osteoporosis.

Kutengera puloteni, zowerengera ziyenera kukhala pakati:

• Albumin: 55 ndi 65% kapena 36 ndi 50 g / L.
• Alpha1 - globulins: 1 ndi 4% mwachitsanzo 1 ndi 5 g / L
• .Alpha 2 – globulins: 6 ndi 10% kapena 4 ndi 8 g/l
• .Beta – globulins: 8 ndi 14% kapena 5 ndi 12 g/L.
• Gamma - globulins: 12 ndi 20% kapena 8 ndi 16 g / L.
  

Electrophoresis idzazindikira magulu a mapuloteni owonjezereka kapena otsika mu seramu. "Puloteni iliyonse yamagazi ipanga magulu a m'lifupi mwake komanso kukula kwake kutengera kuchuluka kwake. "mbiri" iliyonse imatha kutanthauziridwa ndi dokotala. Akhoza, ngati kuli kofunikira, kulembera mayeso owonjezera.

Zosokoneza zomwe zadziwika ndi EPS

Zina mwa zolakwika zomwe zapezeka:

• Kuchepa kwa albumin (hypoalbuminemia), komwe kungayambitsidwe ndi kuperewera kwa zakudya m'thupi, kulephera kwa chiwindi, matenda osatha, myeloma kapenanso kuchuluka kwa madzi (hemodilution).
• Hyper-alpha2-globulinemia ndi kuchepa kwa albumin ndizofanana ndi kutupa. Kuphatikizika kwa tizigawo ta beta ndi gamma kumawonetsa matenda a shuga.
• Kuchepa kwa ma gamma globulins (hypogammaglobulinemia) kumawonedwa ngati chitetezo chamthupi sichikuyenda bwino. Kumbali inayi, kuchuluka kwake kumawonjezeka (hypergammaglobulinemia) mu myeloma, monoclonal gammopathies ndi matenda a autoimmune (lupus, nyamakazi).
• Kuwonjezeka kwa beta globulins kungatanthauze kukhalapo kwa kusowa kwachitsulo, hypothyroidism kapena kutsekeka kwa biliary.

Malinga ndi HAS, tikulimbikitsidwa kutumiza wodwalayo kuti akalandire malangizo ena:

• Ngati wodwala matenda ulaliki akusonyeza hematologic malignancy (kupweteka kwa mafupa, kuwonongeka ambiri chikhalidwe, lymphadenopathy, chotupa syndrome);
• pakakhala vuto lachilengedwe (kuperewera kwa magazi m'thupi, hypercalcemia, kulephera kwaimpso) kapena kujambula (zotupa m'mafupa) zomwe zikuwonetsa kuwonongeka kwa chiwalo;
• ngati palibe zizindikiro zotere, wodwala amene kuyesedwa kwa mzere woyamba ndi kosadziwika bwino, kapena amene serum monoclonal immunoglobulin ndi IgG? 15 g / L, IgA kapena IgM? 10 g / L;
• ngati wodwala ali ndi zaka zosakwana 60.

Chithandizo cha anomaly electrophoresis ndi cha pathology chomwe chimawulula.

"Mwachitsanzo, ngati hyperprotidemia yathunthu chifukwa cha kuchepa kwa madzi m'thupi, mankhwalawo amakhala obwezeretsa madzi m'thupi. Ngati pali kuwonjezeka kwa alpha globulins chifukwa cha matenda otupa, chithandizo chidzakhala chomwe chimayambitsa kutupa. Nthawi zonse, ndi dokotala yemwe, pogwiritsa ntchito kuyezetsa uku komanso mayeso ena owonjezera (kuyezetsa magazi, kuyezetsa magazi, ndi zina zambiri), amadziwitsanso za matendawa ndikulembera chithandizo chogwirizana ndi matendawo. anapeza”.