Rett syndrome ndi matenda osowa majini zomwe zimasokoneza kukula ndi kukhwima kwa ubongo. Imadziwonetsera yokha mu makanda ndi makanda, pafupifupi pakati atsikana.

Mwana yemwe ali ndi matenda a Rett amakula bwino ali mwana. Zizindikiro zoyamba zimawonekera pakati 6 ndi miyezi 18. Ana ndi matenda pang`onopang`ono ndi mavuto zosuntha, kugwirizana ndi kulankhulana zomwe zimakhudza luso lawo lolankhula, kuyenda ndi kugwiritsa ntchito manja. Kenako timalankhula za polyhandicap.

Gulu latsopano la matenda a pervasive Developmental (PDD).

Ngakhale Rett syndrome ndi matenda amtundu, ndi gawo la matenda oyambitsa matenda (PDD). M'kope lotsatira (likubwera la 2013) la Diagnostic and Statistical Manual of Mental Disorders (DSM-V), American Psychiatric Association (APA) ikupereka gulu latsopano la PDD. Mitundu yosiyanasiyana ya Autism idzagawidwa m'gulu limodzi lotchedwa "Autism Spectrum Disorders". Chifukwa chake, matenda a Rett adzatengedwa ngati matenda osowa chibadwa omwe ali osiyana kotheratu.