Zizindikirozi, zomwe zimachitika chifukwa cha kufa kwa ma neuron mu gawo limodzi la ubongo, nthawi zambiri zimawonekera ngakhale zovuta za kukumbukira zisanachitike.
Ofufuza ku Indiana University School of Medicine (USA) avumbulutsa kwa nthawi yoyamba momwe mamolekyu amathandizira kuzizindikiro za neuropsychiatric zomwe nthawi zambiri zimatsogolera kuchepa kwa luntha mu matenda a Alzheimer's. Tikunena za kutayika kwa chilimbikitso, mphwayi, nkhawa, kusinthasintha kwadzidzidzi komanso kukwiya kowonjezereka.
Asayansi amayang'ana kwambiri pa nucleus accumbens, dera laubongo lomwe limagwira ntchito yofunika kwambiri pakupanga mphotho. Zimachokera ku nucleus accumbens zomwe zimatengera chidziwitso cholimbikitsa.
Ofufuza apeza kuti odwala a Alzheimer's ali ndi zolandilira mu nucleus accumbens zomwe zimalola calcium kulowa mu neuroni. Nthawi zambiri, sikuyenera kukhala ndi zolandilira zotere mu nucleus accumbens. Kuchuluka kwa calcium kumabweretsa kufa kwa ma neuron ndi kutayika kwa kulumikizana kwa synaptic pakati pawo, zomwe zimayambitsa zizindikiro za neuropsychiatric.
Kutengera izi, asayansi akuwonetsa kuti kutsekereza kwa calcium receptors mu nucleus accumbens kungalepheretse kapena kuchedwetsa kuyambika kwa matenda a Alzheimer's.
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