La progesterone ndi mahomoni a steroid yomwe imagwira ntchito yofunikira makamaka pakuyika ndi kukonza a pregnancy. Ndikofunikira, ngakhale kunja kwa mimba, kuti asungidwe ntchito ya ziwalo zoberekera.

Amapangidwa makamaka ndi ovary (kupatula mimba) ndi placenta (kuyambira mwezi wachiwiri, kutengapo kuchokera ku thupi lachikasu). Pa nthawi ya mimba, amalola kusamuka kwa dzira la umuna kupita ku chiberekero, ndiye kumathandizira kukhazikitsidwa kwake, mwa zina.

Mlingo wa progesterone m'magazi umasiyanasiyana panthawi ya msambo. Zimakhala zotsika panthawi ya follicular, zimawonjezeka kwambiri panthawi ya luteal, kufika pazipita masiku 5 mpaka 10 pambuyo pa opaleshoni ya LH (hormone ya luteinizing, yomwe imayambitsa ovulation). Mitengo imachepa, kupatula pa mimba.

M'magazi, progesterone imazungulira yomangidwa ndi mapuloteni osiyanasiyana (transcortin, albumin ndi orosomucoid).

Mlingo wa progesterone wamagazi (progestéronémie) zitha kuchitika muzochitika zingapo:

• mwa 20^st ndi 23^st tsiku la msambo, kuwonetsetsa kuti corpus luteum imatulutsa progesterone yokwanira, yofunikira kuti pakhale mimba (ngati mukukayika panthawi yopita padera mobwerezabwereza)
• pa masabata oyambirira a mimba, kuonetsetsa kuti zikuyenda bwino (mlingo uyenera kukhala wokhazikika)
• kuyang'ana mphamvu ya ovulation induction pakubereka mothandizidwa ndi mankhwala
• kuti azindikire ectopic pregnancy (mophatikiza ndi mayeso a hCG), progesterone ndiye yotsika modabwitsa.
• Pankhani ya kubereka mothandizidwa ndi mankhwala, umuna wa in vitro ndi kusamutsa mwana wosabadwayo, kapena kupanga intrauterine insemination (ndi chizindikiro cha ovulation)

Kuyezetsa magazi kumachitika pamiyendo ya venous, makamaka chapakati pa chigongono. Palibe kukonzekera komwe kumafunikira, koma tsiku la nthawi yotsiriza kapena chiyambi cha mimba chiyenera kufotokozedwa.

Monga kalozera, wabwinobwino misinkhu magazi progesterone kunja kwa mimba ndi zosakwana 1,5 ng / ml pa follicular gawo, pakati pa 0,7 ndi 4 ng / ml pa nthawi ya ovulation pachimake ndi pakati pa 2 ndi 30 ng / mL pa luteal gawo (chiwonetsero cha kupezeka kwa corpus luteum).

Iwo amachepa pa kusintha kwa thupi.

Pa mimba, pa 5st sabata yaamenorrhea, iwo ali pafupifupi 40 ng / mL ndi kufika 200 ng / mL kumapeto kwa pregnancy.

Pamene ma progesterone otsika kwambiri apezeka, makamaka kwa amayi omwe akufuna kukhala ndi pakati, zowonjezera zikhoza kuganiziridwa mu gawo lachiwiri la kuzungulira.

Pomaliza, onani kuti progestéronémie zitha kuchulukirachulukira m'matenda angapo, makamaka zotupa zam'mimba kapena zotupa za adrenal kapena zoperewera zina zobadwa nazo.

Dokotala yekha ndi amene adzatha kutanthauzira zotsatira ndi kupanga matenda, nthawi zina mothandizidwa ndi mayesero owonjezera kapena kusanthula.