Timatanthauziraandropause monga zizindikiro zonse za thupi ndi zamaganizo zomwe zingatsatire testosterone paanthu kukalamba. Zitha kuchitika mozungulira 45 kuti 65.

Zizindikirozi zimayambira kuchepetsa chilakolako cha kugonana pakufika kwa mavuto erectile kudzera mukumverera kwakusowa mphamvu ndi kuyendetsa. Nthawi zotuluka thukuta kwambiri, vuto la kusowa tulo komanso kunenepa zitha kuwonjezera zotsatira za kuchepa kwa kupanga kwa mahomoni ogonana.

Amaganiziridwa ngati kusagwira ntchito ndi ena, monga chiwonetsero cha okalamba zachilendo ndi ena, andropause amakhalabe a nkhani yotsutsana. Kuonjezera apo, mankhwala okhawo omwe alipo, testosterone, sanatsimikizidwe, kaya ndi mphamvu kapena chitetezo.

Ndi amuna angati omwe adakhudzidwa?

Popezaandropause sichidziwika bwino ndipo sichidziwika kawirikawiri, tilibe deta yeniyeni ya chiwerengero cha amuna omwe akudwala.

Komabe, malinga ndi kafukufuku wamkulu wofalitsidwa mu 2010, European Male Aging Study, kokha 2% amuna okalamba 40 kuti 80 akukumana ndi andropause: gawoli ndi 3% mwa azaka zapakati pa 60 mpaka 69 ndi 5% mwa azaka 70 mpaka 79.¹. Matendawa adachokera pa kukhalapo kwa zizindikiro za andropause komanso kuchepa kwa testosterone yamagazi.

Zotsatirazi zikuwonetsa kuti chithandizo cha testosterone ndi choyenera kwa amuna ochepa kwambiri, malinga ndi olemba a phunziroli.¹². Nthawi zambiri, malinga ndi zomwe akuwona, zizindikirozo zimagwirizana kwambiri ndi ukalamba, kunenepa kwambiri kapena vuto lina la thanzi. Ndipotu, 20% mpaka 40% ya amuna amakula zizindikiro akhoza kufanana ndi andropause ndi zaka¹¹.

Zoonadi funso la testosterone?

La testosterone amaperekedwa ngati chithandizo paandropause kwa zaka zoposa khumi. Cholinga cha chithandizo ndikuwongolera moyo mwa kuchepetsa zizindikiro. Makampani opanga mankhwala amatsutsa kuti testosterone imathanso kuchedwetsa njira ya okalamba : kuchepa kwa minofu ya minofu ndi chiopsezo cha fractures, mphamvu zambiri zogonana, kuphatikizapo erections yabwino, etc. Komabe, zotsatirazi sizinawonetsedwe mwasayansi.

Nazi zifukwa zazikulu zomwe zimapanga chithandizo cha andropause nkhani yovuta komanso yovuta:

• Le testosterone levels zomwe zimasonyeza "kuperewera" kwa amuna azaka zapakati sizikudziwika. Komanso, mlingo umenewu umasiyana munthu ndi munthu. Masikelo omwe akugwiritsidwa ntchito pano ali ndi kulakwitsa kwakukulu ndipo amachokera ku chiwerengero chokhazikitsidwa kwa anyamata;
• Palibe ayi zizindikiro makamaka kwa andropause. Mwa kuyankhula kwina, zizindikiro zonse zomwe zimakhalapo zingakhale zotsatira za matenda ena, monga kuvutika maganizo, mavuto a mitsempha kapena kunenepa kwambiri;
• Kugwirizana pakati pa testosterone yotsika ndi zizindikiro za andropause ndikofooka, malinga ndi maphunziro osiyanasiyana. Amuna omwe ali ndi ma testosterone abwinobwino amatha kukhala ndi zizindikiro za andropause. Akatswiri ena amakhulupirira kuti zizindikiro za andropause nthawi zambiri zimakhala zotsatira za zoipa zizolowezi za moyo^{2, 11};
• The ubwino ndi zoopsa chithandizo cha testosterone sichimakhazikitsidwa momveka bwino ndi mayesero a zachipatala, aifupi komanso aatali. Akatswiri ena amati testosterone hormone therapy ndi malo okwera mtengo chabe¹². Choopsa chachikulu ndi mankhwalawa mwa amuna akuluakulu ndikuti mumawonjezera chiopsezo cha khansa ya prostate kapena sitiroko. Izi ndichifukwa choti testosterone imachulukitsa kuchuluka kwa hemoglobin ndipo imatha kusintha pang'ono kuchuluka kwa lipid m'magazi, ndikuwonjezera chiopsezo cha kuundana kwa magazi mumtsempha wamagazi muubongo. Zowopsa zina zomwe zatchulidwa ndi izi: kuwonongeka kwa chiwindi, kukula kwa bere (komwe kumatha kukhala kowawa), testicular atrophy, kuchuluka kwaukali kapena kusagwirizana ndi anthu komanso kuipiraipira kwa matenda omwe alipo kale (kupumira tulo, misala, kupsinjika maganizo, etc. etc. etc.). Mofanana ndi mahomoni omwe amaperekedwa kwa amayi omwe ali ndi postmenopausal, ndizotheka pambuyo pake kuti mankhwalawa a testosterone amakhala ndi zoopsa zina zaumoyo. Maphunziro ali mkati;
• Kusintha kwina kwa mahomoni kumatha kufotokozera zotsatira za andropause. DHEA (dehydroepiandrosterone), hormone ya kukula, melatonin ndipo, pamlingo wocheperapo, mahomoni a chithokomiro amakhudzanso mphamvu zawo.

matenda

Kuchiza kwaandropause pokhala posachedwapa, njira zomwe zimatsogolera ku matendawa zilibe maziko olimba asayansi.

Adotolo amafunsa kaye za zizindikiro anamva ndi wodwala wake. Angagwiritse ntchito mafomu ena owunikira kuti awonetse bwino kukula kwa zizindikiro, monga kuyesa kwa AMS (kwa Aging Male Score) kapena kuyesa kwa ADAMU (kwa Kuperewera kwa Androgen kwa Amuna Okalamba). Kuti muwone mayesowa, onani gawo la Sites of chidwi.

Uwu ndi mwayi wabwino kukhazikitsa a fufuzani thanzi lonse : kuyezetsa magazi (mbiri ya lipid, mahomoni a chithokomiro, antigen yeniyeni ya prostate, ndi zina zotero), chithunzi cha thanzi la mtima wamtima, mwachidule za moyo. Mndandanda wa mankhwala ndi mankhwala achilengedwe omwe amadyedwa adzamaliza chithunzicho. Kuwunikaku kumathandizira kusiya zina zomwe zingayambitse zizindikiro zomwe zimamveka (kuchepa kwa magazi, kukhumudwa, hypothyroidism, matenda otopa kwambiri, zovuta zakuyenda kwa magazi, zotsatira za mankhwala osokoneza bongo, etc.).

Mayeso a magazi

Nawa mafotokozedwe ena okhudza mayeso omwe amagwiritsidwa ntchito kuti awone ngati pali kuchepa kwa testosterone.

Malinga ndi International Society for the Study of Aging Male (ISSAM), mayeso omwe cholinga chake ndi kuyeza magulu a testosterone a magazi ziyenera kukhala mbali ya matenda chifukwa zizindikiro sizingakhale zokhudzana ndi andropause³. Koma mayeserowa amachitidwa pokhapokha ngati zizindikiro zambiri zikuwonekera.

• Magulu onse a testosterone. Zotsatira za mayesowa zikuphatikiza ma testosterone onse omangidwa kwa transporter (the mahomoni ogonana omwe amamanga globuline kapena SHBG ndipo, pang’ono, albumin) ndi testosterone yomwe imayendayenda momasuka m’magazi;
• Ma testosterone aulere. Kuyeza kumeneku ndikofunikira chifukwa ndi testosterone yaulere yomwe imagwira ntchito m'thupi. Pafupifupi, pafupifupi 2% ya testosterone imayenda momasuka m'magazi. Palibe mayeso omwe amayesa mwachindunji mlingo wa testosterone yaulere. Choncho madokotala amayerekezera powerengera: amayezera mlingo wa mahomoni ogonana omwe amamanga globuline (SHBG) m'magazi ndikuchotsa pamlingo wa testosterone wathunthu.