La bilirubin ndi pigment osasungunuka m'madzi amtundu wachikasu, chifukwa cha kuwonongeka kwahemogulobini. Ndilo utoto waukulu wa ya ndulu. Amapangidwa m'maselo a thupi mitengo ndi m’mafupa, ndipo kenaka amasamutsidwa kupyola m’mwazi ndi albumin kupita kuchiŵindi. Akapezeka m'chiwindi, amalumikizidwa ndi gluconic acid ndipo amasungunuka m'madzi. M'matumbo, conjugated bilirubin imapatsa chopondapo mtundu wa bulauni.

Dokotala adzayitanitsa kuyezetsa magazi kwa bilirubin ngati akukayikira, mwachitsanzo:

• matenda a hepatobiliary: zinthu zomwe zimakhudza chiwindi (chiwindi chofala kwambiri) ndi / kapena ma ducts a bile
• hemolytic syndromes (yomwe imadziwika ndi kuwonongeka kwachilendo kwa maselo ofiira a magazi)
• kapena jaundice wa wakhanda, wotchedwanso jaundice wa wakhanda

Pakuyezetsa bilirubin, kuyezetsa magazi kuyenera kuchitidwa, komwe kumakhala ndi kuyezetsa magazi kwa venous. Ndibwino kuti musadye kapena kumwa osachepera maola 4 musanayambe kuyezetsa magazi. Dokotala angafunsenso wodwalayo kuti asiye kumwa mankhwala ena omwe angasokoneze zotsatira za kuyesa kwa bilirubin.

Kuchuluka kwa bilirubin m'magazi nthawi zambiri kumakhala pakati pa 0,3 ndi 1,9 mg / dl (mamiligalamu pa desilita iliyonse). Kuchuluka kwa conjugated bilirubin (yomwe imatchedwanso mwachindunji bilirubin) nthawi zambiri imakhala pakati pa 0 ndi 0,3 mg / dl. 

Dziwani kuti zomwe zimatchedwa zabwinobwino za bilirubin m'magazi zimatha kusiyanasiyana kutengera ma labotale omwe amawunika.

Ndi dokotala yekha amene angatanthauzire zotsatira zake ndikukupatsani matenda.

Ngati bilirubin ili pamwamba, imatchedwahyperbilirubinémie.

Ikhoza kukhala:

• kutsogola kwa mawonekedwe aulere (mwa kupanga mopitilira muyeso kapena kusowa kolumikizana):

- Ngozi transfusionnels

- hemolytic anemia: poizoni, mankhwala, parasitic hemolysis, etc.

Matenda a Gilbert (matenda a bilirubin metabolism)

- jaundice wa wakhanda

- Criggler-Najjar syndrome (matenda obadwa nawo a bilirubin metabolism)

• Kuchulukira kwa mawonekedwe olumikizana (conjugated bilirubin imatulutsidwa m'magazi pamene njira yabwinobwino yotulutsira yatsekedwa):

- ndulu

- neoplasia (khansa)

- pancreatitis

- hepatitis yapoizoni, hepatitis ya mowa, hepatitis ya virus

- matenda enaake

Mmodzi amasiyanitsa makamaka "jaundice yokhala ndi bilirubin yaulere", yomwe imakhala chifukwa cha kuwonongeka kwakukulu kwa maselo ofiira a m'magazi (hemolysis) a "jaundice ndi conjugated bilirubin", m'malo mokhudzana ndi matenda a biliary kapena chiwindi.