Le fibrinogen ndi mapuloteni magazi omwe amagwira nawo ntchito kusokonekera. Amatenga nawo mbali pa maphunziro a magazi kuundana komanso modulates ntchito ya othandiza magazi kuundana ndi selo wa ziwiya. Pansi pa zochita za mapuloteni ena, ndi thrombin, imasanduka fibrin

Amapangidwa ndi maselo a chiwindi. Mlingo wake m'magazi nthawi zambiri umachokera ku 2 mpaka 4 g / l. Komabe, kaphatikizidwe ka izi mapuloteni akhoza kuwonjezeka chifukwa cha kupsinjika maganizo, panthawi yomwe ali ndi pakati, kapena pambuyo pobaya mankhwala enaake kapena kukula kwa hormone. Kuwonjezeka kwa mlingo wa fibrinogen m'magazi kumasonyezanso za kutupa.

Fibrinogen assay imasonyezedwa kuti iwonetsetse vuto la kutsekeka kwa magazi (mwachitsanzo ngati magazi akutuluka mosadziwika bwino kapena ” defibrination syndrome », Zogwirizana ndi vuto la coagulation).

Pali zilema zitatu zobadwa m'magulu a fibrinogen:

• THEafibrinogenemia, ndiko kusakhalapo kwathunthu kwa fibrinogen. Matenda osowawa amayambitsa magazi ochuluka omwe amachitika pobadwa
• THEhypofibrinogenemia, zofanana ndi kuchepa kwa mlingo wa fibrinogen m'magazi (ichi ndi chilema mu katulutsidwe, nthawi zambiri)
• La dysfibrinogenemia, chomwe ndi kusokonekera kwa mapuloteni.

Kuyezetsa magazi kwa fibrinogen kungakhale kothandiza ngati:

• yotupa matenda
• kulephera kwa chiwindi (zomwe zimayambitsa kuchepa kwa milingo ya fibrinogen)
• kuyang'anira zotsatira za mankhwala otchedwa "fibrinolytic", omwe cholinga chake ndi kusungunula magazi a magazi pakachitika thrombosis.

Mlingo wa fibrinogen imachitidwa pa sampuli ya magazi a venous (kuyesa magazi), mu labotale yowunikira zamankhwala. Mlingo ndi muyeso wanthawi zonse ndipo zotsatira zake nthawi zambiri zimapezeka mkati mwa tsiku.

Dokotala yekha ndi amene angathe kutanthauzira zotsatira za kusanthula.

Nthawi zambiri, kuchuluka kwa fibrinogen (hyperfibrinogenemia) akhoza kuwonedwa ngati kutupa, ngati matenda ena opatsirana (chibayo, etc.), ngati matenda a rheumatic fever kapena autoimmune matenda (lupus), pambuyo pa infarction ya myocardial, etc.

Mosiyana ndi zimenezi, hypofibrinogenemia (kuchepa kwa mlingo wa fibrinogen) kungasonyeze matenda a majini, kulephera kwa chiwindi kwambiri (hepatitis, cirrhosis), matenda a coagulation (kufalitsa intravascular coagulation kapena defibrination syndrome) kapena "fibrinolysis", mwachitsanzo chifukwa cha khansa.