The transaminases ndi e alipo mkati selo, makamaka m'chiwindi ndi minofu. Iwo amatenga nawo mbali pazambiri za zochitika zamoyo.

Pali mitundu iwiri ya transaminases:

• ndi ASAT (aspartate aminotransferases), yomwe imapezeka makamaka m'chiwindi, minofu, mtima, impso, ubongo ndi kapamba.
• ndi ALT (alanine aminotransferases), makamaka ku chiwindi

Ma ASAT adasankhidwa kale ndi mawu oti TGO (kapena SGOT a serum-glutamyl-oxaloacetate-transferase); ALATs pansi pa TGP (kapena SGPT ya serum-glutamyl-pyruvate-transaminase).

Kuyesa kwa ma enzymeswa kumagwiritsidwa ntchito kuti azindikire vuto la chiwindi: kuchuluka kwawo kwa magazi kumachitika chifukwa cha kutulutsidwa kwachilendo ndi maselo owonongeka a chiwindi, mwachitsanzo chifukwa cha hepatitis, Pa mowa kapena mankhwala osokoneza bongo, Ndi zina zotero.

Choncho, dokotala akhoza kupereka mlingo ngati zizindikiro zambiri monga kutopa, kukomoka, nseru, jaundice (jaundice), ndi zina zotero.

• chiopsezo cha hepatitis B kapena C,
• kugwiritsa ntchito mankhwala osokoneza bongo,
• kunenepa kwambiri,
• matenda ashuga,
• matenda a autoimmune,
• kapena kutengera matenda a chiwindi.

Mlingo umapangidwa pamiyeso yosavuta yamagazi, yomwe nthawi zambiri imatengedwa kumapindika pachigongono. Palibe zinthu zapadera zomwe zimafunikira pa chitsanzochi (koma zoyeserera zina zomwe zafunsidwa mu lipoti lomwelo zingafunike kuti musala kudya, mwachitsanzo).

Kutsimikiza kwa ma transaminase awiriwa kudzachitika nthawi imodzi, ndipo chiŵerengero cha ASAT / ALAT chidzawerengedwa, chifukwa chimapereka zizindikiro za mtundu wa zilonda kapena matenda a chiwindi omwe akukhudzidwa.

Pakachitika zotsatira zachilendo, mayeso achiwiri mwina adzafunsidwa kuti atsimikizire zikhalidwe.

Pamene kuchuluka kwa ASAT komanso makamaka ALT ndikwambiri, izi nthawi zambiri zimakhala chizindikiro cha kuwonongeka kwa chiwindi.

Komabe, matenda ena, monga matenda a chiwindi omwe amayamba chifukwa cha methotrexate kapena matenda a chiwindi C aakulu, sangatsatire ndi kuwonjezeka kulikonse kwa ma transaminase.

Kuchuluka kwa kukwera kwa transaminase nthawi zambiri kumapatsa dokotala zidziwitso zabwino za matendawa:

• A kukwera pang'ono (zosakwana 2 mpaka 3 nthawi yanthawi zonse) mpaka 3 mpaka 10 kuwirikiza kawiri (nthawi 2 mpaka XNUMX) zomwe zimawonedwa ndi vuto la chiwindi chokhudzana ndi mowa, matenda a chiwindi a virus, kapena steatosis (kuchuluka kwamafuta m'chiwindi), mwachitsanzo. Kumbali inayi, chiŵerengero cha ASAT / ALAT> XNUMX chimasonyeza matenda a chiwindi chauchidakwa.
• A kukwera kwakukulu (oposa 10 mpaka 20 nthawi zonse) amafanana ndi chiwopsezo cha matenda a chiwindi (chiwopsezocho chikhoza kukhala chofunikira kwambiri mkati mwa masabata 4 mpaka 6 pambuyo pa kuipitsidwa), ndi zotupa zomwe zimayambitsidwa ndi mankhwala kapena kuledzera, komanso "hepatic ischemia (kusiya pang'ono kwa magazi kupita kuchiwindi).

Dokotala atha kuyitanitsa mayeso ena kapena mayeso kuti atsimikizire za matendawa (monga biopsy ya chiwindi, mwachitsanzo). The mankhwala anayambitsa ndithudi zimadalira matenda funso.