Fecal elastase ndi puloteni yopangidwa ndi kapamba yomwe imathandizira pakugayidwa kwa chakudya. Mlingo wake umapangitsa kuti athe kuwunika momwe ntchito ya kapamba imayenderana ndi chimbudzi.

Pancreas ndi chiwalo cha thupi la munthu chomwe chili ndi ntchito ziwiri:

• ntchito ya endocrine ya 10% ya maselo: kapamba amatulutsa insulini ndi glucagon, mahomoni awiri omwe amayang'anira kuchuluka kwa shuga m'magazi. Insulin imachepetsa shuga m'magazi pomwe glucagon imawonjezera. Mahomoni awiriwa amathandiza kuti shuga m’magazi asamayende bwino. Ngati pali vuto ndi katulutsidwe ka insulini, timalankhula za shuga;
• ntchito ya exocrine ya 90% yama cell: by ma cell acinar, kapamba amatulutsa michere ya pancreatic, mapuloteni omwe ali ndi gawo linalake. Ma enzymes awa ndi gawo la timadziti ta pancreatic ndipo ndi ofunikira kuti chakudya chigayidwe moyenera. Kupyolera mu kukondera kwa njira za Wirsung ndi Santorini, timadziti ta pancreatic timasiya kapamba kuti tibwere ndikusakanikirana ndi bile m'matumbo. M’chigayo cha m’mimba, ma enzyme amenewa amatenga nawo gawo m’kugaya mafuta, mapuloteni ndi chakudya chamafuta mwakuwagaŵa m’zinthu zambiri, zoloŵetsedwa mosavuta ndi thupi.

Fecal elastase ndi amodzi mwa ma enzyme omwe amapangidwa ndi kapamba. Amapangidwa mokhazikika komanso mosalekeza, zomwe zimapangitsa kukhala chizindikiro chabwino cha kapamba. Cholinga cha fecal elastase assay ndikuwunika momwe ntchito ya exocrine ya kapamba imagwirira ntchito. Mtengo wotchulidwa ndi ma 200 ma micrograms pa gramu ya choponda mwa akulu ndi ana (kuyambira mwezi umodzi). Mtengo uwu ndi wokhazikika ndipo umasiyana pang'ono kuchokera tsiku limodzi kupita ku lina mwa munthu yemweyo kupatula ngati kutsekula m'mimba kwambiri komwe kumachepetsa mlingo wa fecal elastase. Pankhaniyi, kusanthula kuyenera kubwerezedwa. Ndi mayeso osavuta kuchita, omwe amalola kuti alowe m'malo mwa mayeso ena ovuta kwambiri monga kafukufuku wa steatorrhea.

Kuyesa uku kumachitidwa kuti awone momwe ntchito ya exocrine ya kapamba imagwirira ntchito. Mwachitsanzo, zitha kuchitika ngati mukukayikira kuti exocrine pancreatic insufficiency. Angathenso kufunsidwa ndi dokotala kuti adziwe zomwe zimayambitsa vuto lotsegula m'mimba.

Kutsimikiza kwa faecal elastase kumachitika pazitsanzo za ndowe. Wodwala akhoza kutenga chitsanzo kunyumba kwake ndi zinthu zoperekedwa ndi labotale yowunikira zamankhwala. Kenako adzasiya mwamsanga chitsanzocho mu labotale kuti akaunike. Chitsanzocho chiyenera kusungidwa pa 4 ° C (mufiriji). Kusanthula kuyenera kuchitika mkati mwa maola 48 kuchokera pakutolera ndodo. Awa ndi mayeso amtundu wa ELISA, omwe amayesa elastase yamunthu (elastase E1). Mayesowa amakhala ndi kulekanitsa puloteni pakati pa ma antibodies awiri, aliyense amazindikira kachidutswa kakang'ono ka puloteni, motero kumapangitsa kuti azindikire ndikuwerengera.

Ngati wodwalayo athandizidwa ndi chithandizo chothandizira ma enzyme, izi sizikhudza mlingo wa fecal elastase. Mosiyana ndi zimenezi, zinthu zina ziyenera kupewedwa sabata isanayambe komanso tsiku lachitsanzo:

• kuyezetsa kwa radiological m'mimba;
• kukonzekera colonoscopy;
• mankhwala ofewetsa tuvi tolimba;
• kuvala m'mimba kapena mankhwala oletsa kutsekula m'mimba. Zoonadi, zinthuzi zimatha kusintha matumbo a m'mimba kapena kusokoneza zotsatira za kusanthula.

Momwemonso, ndi bwino kupewa, ngati n'kotheka, kuyezetsa kumeneku panthawi yotsekula m'mimba kwambiri. Ngati izi sizingatheke, ziyenera kuwonetsedwa kuti adokotala aziganizira pofufuza zotsatira.

Kutsika kwambiri kwa fecal elastase (kupatula kutsekula m'mimba) kumawonetsa kusakwanira mu ntchito ya exocrine ya kapamba. Kuphatikizika pakati pa 150 ndi 200 μg / g ndi chizindikiro cha kusakwanira kwapang'onopang'ono kwa exocrine. Timalankhula za kusakwanira kwakukulu kwa pancreatic exocrine pomwe mulingo wa fecal elastase ndi wosakwana 15 μg / g.

Kuchokera pamenepo, dokotala adzafunika kuyesanso, kuyesa ndi kujambula kuti adziwe chomwe chimayambitsa kusakwanira uku. Pali zambiri zotheka:

• pancreatitis yosatha;
• pachimake kapamba;
• enaake fibrosis;
• shuga;
• matenda a celiac;
• Matenda a Crohn;
• Zollinger-Ellison syndrome;
• chapamwamba m`mimba opaleshoni thirakiti;
• etc.