Monga mankhwala ndi zitsamba zophikira, sage yadziwika kwa nthawi yayitali kuposa zitsamba zina zambiri. Aigupto akale ankagwiritsa ntchito ngati mankhwala achilengedwe a chonde. M’zaka za zana loyamba AD, sing’anga wachigiriki Dioscorides anagwiritsira ntchito decoction of sage kaamba ka mabala otuluka mwazi ndi kuyeretsa zilonda. Sage amagwiritsidwanso ntchito kunja ndi herbalists kuchiza sprains, kutupa, ndi zilonda.
Sage adalembedwa mwalamulo mu USP kuyambira 1840 mpaka 1900. Pamiyeso yaying'ono komanso yobwerezedwa nthawi zambiri, sage ndi mankhwala ofunikira a malungo ndi chisangalalo chamanjenje. Chithandizo chodabwitsa chomwe chimapangitsa kuti m'mimba mwakhumudwitse ndikupangitsa kuti chimbudzi chikhale chofooka nthawi zonse. Mafuta a sage, tincture ndi mafuta ofunikira amawonjezedwa ku mankhwala okonzekera pakamwa ndi pakhosi, komanso mankhwala a m'mimba.
Sage imagwiritsidwa ntchito pochiza matenda apakhosi, zilonda zam'mano, ndi zilonda zamkamwa. Ma phenolic acids a sage ali ndi mphamvu yolimbana ndi Staphylococcus aureus. M'maphunziro a labotale, mafuta a tchire amagwira ntchito motsutsana ndi Escherichia coli, Salmonella, bowa wa filamentous monga Candida Albicans. Sage imakhala ndi astringent effect chifukwa cha kuchuluka kwake kwa tannins.
Sage imakhulupirira kuti ndi yofanana ndi rosemary mu mphamvu yake yopititsa patsogolo ubongo ndi kukumbukira. Pakafukufuku wokhudza odzipereka athanzi 20, mafuta a sage adakulitsa chidwi. European Herbal Science Collaboration ikulemba kugwiritsa ntchito tchire kwa stomatitis, gingivitis, pharyngitis ndi thukuta (1997).
Mu 1997, National Institute of Herbalists ku UK idatumiza mafunso kwa akatswiri awo azachipatala. Mwa anthu 49 omwe adafunsidwa, 47 adagwiritsa ntchito sage pochita zawo, pomwe 45 adalamula kuti azitha kusintha.