Hormone yolimbikitsa ya follicle, kapena FSH, ndi mahomoni ofunikira pakubereka mwa amuna ndi akazi. Ichi ndichifukwa chake pakuwunika kwa chonde, kuchuluka kwake kumawunikiridwa mwadongosolo.

Mwa akazi

HSF imapezeka mu gawo loyamba la ovarian cycle, yotchedwa follicular phase. Panthawi imeneyi, yomwe imayamba pa tsiku loyamba la msambo ndi kutha pa nthawi ya ovulation, hypothalamus imatulutsa timadzi timene timatulutsa timadzi ta GnRH (gonadotropin release hormone). A chain reaction adzatsatira:

• GnRH imayambitsa pituitary gland, yomwe imatulutsa FSH;
• mothandizidwa ndi FSH, pafupifupi makumi awiri a ovarian follicles adzayamba kukula;
• ma follicles okhwimawa nawonso adzatulutsa estrogen, yomwe imayambitsa kukhuthala kwa chiberekero kuti akonzekeretse chiberekero kuti chilandire dzira lotheka;
• mkati mwa gulu, follicle imodzi, yotchedwa dominant follicle, imakwaniritsa ovulation. Enawo adzathetsedwa;
• pamene chigawo chachikulu cha preovulatory follicle chasankhidwa, kutulutsa kwa estrogen kumawonjezeka kwambiri. Kuwonjezeka kumeneku kumayambitsa kukwera kwa LH (luteinizing hormone) yomwe imayambitsa ovulation: follicle yokhwima imasweka ndikutulutsa oocyte.

Pakatikati pa machitidwe awa, FSH ndiye mahomoni ofunikira pakubereka.

Mwa anthu

FSH imakhudzidwa ndi spermatogenesis ndi katulutsidwe ka testosterone. Imalimbikitsa ma cell a Sertoli omwe amatulutsa umuna mu ma testes.

Mwa akazi, Mlingo wa FSH ukhoza kuperekedwa muzochitika zosiyanasiyana:

• pakakhala kuyambika kwa amenorrhea ndi / kapena kutha msinkhu: mlingo wophatikizika wa FSH ndi LH umachitika kuti athe kusiyanitsa pakati pa choyambirira (chochokera ku ovarian) kapena sekondale (chiyambi chachikulu: hypothalamus kapena pituitary) hypogonadism;
• ngati pali amenorrhea yachiwiri;
• pakakhala vuto la kubereka, kuyezetsa kwa mahomoni kumachitika ndi mlingo wa mahomoni ogonana osiyanasiyana: follicle stimulating hormone (FSH), estradiol, luteinizing hormone (LH), antimulleric hormone (AMH) ndi nthawi zina prolactin, TSH (chithokomiro). ), testosterone. Kuyezetsa kwa FSH kumathandizira kuwunika kwa ovary reserve komanso mtundu wa ovulation. Zimalola kudziwa ngati vuto la ovulation kapena amenorrhea limachitika chifukwa cha ukalamba wa ovarian kapena kukhudzidwa kwa gland ya pituitary.
• pakutha kwa msambo, kutsimikiza kwa FSH sikuvomerezedwanso kutsimikizira kuyambika kwa premenopause ndi menopause (HAS, 2005) (1).

Mwa anthu

Kuyesa kwa FSH kumatha kuchitidwa ngati gawo loyesa kubereka, poyang'anizana ndi vuto la spermogram (azoospermia kapena oligospermia yoopsa), kuti muzindikire hypogonadism.

Miyezo ya mahomoni amatengedwa poyezetsa magazi, osati pamimba yopanda kanthu.

• mwa akazi, kutsimikiza kwa FSH, LH ndi estradiol kumachitika pa 2, 3rd kapena 4th tsiku la kuzungulira mu labotale yowunikira.
• mwa anthu, mlingo wa FSH ukhoza kuchitidwa nthawi iliyonse.

Mwa akazi:

• kuwonjezeka kwakukulu kwa FSH ndi LH kumasonyeza kulephera kwakukulu kwa ovarian;
• kuchepa kwakukulu kwa LH ndi FSH nthawi zambiri kumawonetsa kuwonongeka kwa pituitary gland, primary kapena secondary (chotupa, pituitary necrosis, hypophysectomy, etc.);
• ngati FSH ili pamwamba komanso / kapena estradiol yotsika, kuchepa kwa ovarian reserve kumaganiziridwa ("kusiya kusamba koyambirira").

Mwa anthu:

• FSH yapamwamba imasonyeza kuwonongeka kwa testicular kapena seminiferous tubular;
• ngati ili yochepa, kukhudzidwa "kwapamwamba" (hypathalamus, pituitary) kumaganiziridwa. MRI ndi kuyezetsa magazi kowonjezera kudzachitidwa kuti muwone ngati pituitary insufficiency.

Mwa akazi:

• ngati dzira la dzira lalephera kapena kukhudzidwa kwa chithokomiro cha pituitary, chithandizo chokondoweza cha ovarian chidzaperekedwa. Cholinga chake ndi kupanga ma oocyte okhwima amodzi kapena awiri. Pali ma protocol osiyanasiyana, kudzera pakamwa kapena jakisoni;
• pakachitika kusintha kwa msinkhu msanga, chopereka cha oocyte chingaperekedwe.

Mwa anthu:

• pakachitika hypogonatotropic hypogonadism (kusintha kwa hypotalamic-pituitary axis) ndi azoospermia yoopsa kapena oligospermia, chithandizo chobwezeretsa umuna chidzaperekedwa. Mitundu iwiri ya mamolekyu ingagwiritsidwe ntchito: gonadotropins ndi FSH ntchito ndi gonadotropins ndi LH ntchito. Ma protocol, omwe amasiyana malinga ndi wodwala, amatha miyezi 3 mpaka 4, kapena kupitilira nthawi zina.
• pakachitika kusintha kwakukulu kwa umuna ndi azoospermia (zomwe zingatheke kuchotsa umuna mu epididymis kapena testis), IVF ndi ICSI ikhoza kuperekedwa. Njira ya AMP iyi imakhala ndi kubaya ubwamuna mwachindunji mu cytoplasm ya oocyte wokhwima;
• Kupereka umuna kungaperekedwe kwa okwatiranawo ngati umuna sungathe kubwezeretsedwa.