Mankhwala omwe amalepheretsa ntchito ya chitetezo cha mthupi - gamma interferon amalepheretsa kukula kwa melanoma - khansa yapakhungu yoopsa - malinga ndi asayansi aku US mu nyuzipepala ya Nature.
Kuwonekera kwa kuwala kwa ultraviolet ndi cheza ndi zinthu ziwiri zomwe zimayambitsa kukula kwa melanoma - khansa yapakhungu yoopsa kwambiri. Tsoka ilo, mpaka pano njira zama cell zakukula kwa khansa iyi sizinamvetsetsedwe bwino.
Glenn Merlino ndi ogwira nawo ntchito ku National Cancer Institute ku Bethesda adaphunzira zotsatira za radiation ya UVB mu mbewa. Asayansi awonetsa kuti UVB imapangitsa kuti macrophages aziyenda pakhungu. Macrophage ndi mtundu wa maselo oyera a magazi, maselo omwe amapanga interferon gamma, puloteni yomwe imazindikiritsa kukula kwa melanoma.
Kuletsa ntchito ya interferon gamma (ie interferon mtundu II) mothandizidwa ndi ma antibodies oyenera amalepheretsa kukula kwapakhungu ndi kukula kwa khansa, kuletsa kwa interferon I ntchito kulibe zotsatirapo.
Ma interferon a Type I amadziwika kuti ndi mapuloteni odana ndi khansa ndipo imodzi mwa izo, interferon alpha, imagwiritsidwa ntchito pochiza melanoma. Kupeza kuti gamma interferon ili ndi zotsatira zosiyana ndipo imalimbikitsa chitukuko cha khansa ndizodabwitsa. Kuletsa kwa gamma interferon kapena mapuloteni omwe amakhudza kumawoneka ngati chandamale chabwino cha chithandizo cha melanoma. (PAP)