- Mapiritsi amakono a anti-androgen ndi othandiza kwambiri - pafupifupi pafupifupi gawo lililonse la chithandizo amatha kuchepetsa matendawa, kukulitsa moyo komanso kulekerera bwino. Tikulankhula ndi Dr. Iwona Skoneczna, PhD, za mankhwala atsopano a mahomoni omwe sanapezekebe ku Poland.
Dokotala, khansa ya prostate yakhala ikupha anthu ambiri ku Poland kwa zaka zambiri. Chimodzi mwa zifukwa ndi "kukana kwa amuna", mwachitsanzo, kuopa dokotala wa urologist, ndipo chinacho ndi chochepa chopeza chithandizo chamakono. Kodi odwala aku Poland amaphonya chiyani kwambiri?
Kupulumuka ndi kufa kwa ma neoplasms kumadalira pazifukwa zambiri, koma kawirikawiri tinganene kuti chinthu chofunika kwambiri ndi gawo la chitukuko cha matenda pa nthawi ya matenda ndi kuthekera kogwiritsa ntchito bwino, kawirikawiri mankhwala osiyanasiyana. Mliriwu udawonjezera zovuta zowunikira momwe abambo ambiri adakakamizidwira kukayezetsa mkodzo.
Ndikufuna kubwerezanso kuti khansa ya prostate yoyambirira simayambitsa zizindikiro zilizonse ndipo ngati sitiyesa kufufuza ngati tilibe tokha, zingatidabwitse ndikupanga ma metastases tisanadziwe. Chinthu chinanso chofunikira chomwe chimatsogolera ku zotsatira zabwino za chithandizo, makamaka mu khansa ya prostate yapamwamba, ndi kupeza chithandizo chamakono. Panonso, ngakhale kuti zinthu zasintha, pali zambiri zomwe zingatheke.
Kupambana pochiza khansa ya prostate ndikukhala antiandrogens amakono - amagwira ntchito bwanji?
Takhala tikudziwa kwa zaka zoposa 50 kuti kukula kwa khansa ya prostate kumadalira kukhalapo kwa mahomoni achimuna, makamaka testosterone. Ma androgen receptors m'maselo a khansa amatenga ma androgens ndipo khansa imakula mwachangu. Chithandizo choyamba ndikuchepetsabe ma testosterone. Komabe, pakapita nthawi, izi zimatha, ndipo maselo a khansa amatulutsa ma androgens awo kapena amayamba kuchulukitsa paokha.
Komabe, zikuwoneka kuti ndiye kuti cholandilira cha androgen chikhoza kutsekedwa kosatha ndipo kukula kwa chotupa kumacheperanso. Mapiritsi amakono odana ndi androgen ali ndi zotsatira zotere, ndi othandiza kwambiri, chifukwa pafupifupi pa gawo lililonse la chithandizo amatha kuchepetsa matendawa, kuwonjezera moyo komanso kulekerera bwino.
Ndi odwala ati omwe angapindule kwambiri ndi mankhwala atsopano a mahomoni?
Mu oncology, timayesa kuzindikira zizindikiro zakuyambiranso koyambirira kuti tithe kuthana ndi chitukuko cha ma clones osamva mwachangu momwe tingathere. Mu khansa ya prostate yomwe imathandizidwa ndi opaleshoni kapena chithandizo cha radiation, kukwera kwa PSA kumakhala chizindikiro choyambirira chakuyambiranso. Ngati PSA ikupitirizabe kuwonjezeka ngakhale kuchepa kwa testosterone, makamaka ikawonjezeka pasanathe miyezi 10, ndipo sitinawone ma metastases poyesa kuyesa kujambula (tomography ndi bone scintigraphy), malinga ndi chidziwitso chachipatala, ndi nthawi yogwiritsira ntchito zatsopano. mankhwala a mahomoni (apalutamide, darolutamide kapena enzalutamide). Akapatsidwa kwa odwala panthawiyi, amachedwetsa kuyambika kwa metastasis ndi zaka 2 ndikuwonjezera pafupifupi chaka kuti apulumuke.
Kodi ubwino wa chithandizo chamankhwala cham'kamwa chatsopano kuposa chemotherapy ndi chiyani?
Ndizovuta kuyerekeza mankhwala amphamvu a mtsempha ndi mankhwala a m'badwo wotsatira. Mankhwala onsewa ndi opindulitsa ndipo ndi bwino kugwiritsa ntchito zonsezo. Ndikoyenera kukambirana za dongosolo la chithandizo ndi oncologist, pakalipano komanso mtsogolo. Pankhani ya matenda aukali, chemotherapy nthawi zambiri imaperekedwa ngati chithandizo choyamba, pamene matenda ochepa asymptomatic, tikhoza kuyamba ndi mankhwala a mahomoni.
Ndi njira ziti zomwe wodwala ayenera kukwaniritsa kuti athe kulandira njira zatsopano zochizira khansa ya prostate ku Poland?
Thandizo lamakono la mahomoni a khansa ya prostate mu gawo la kukana kutsika kwa testosterone limapezeka kokha kwa odwala omwe amakwaniritsa zofunikira zazomwe zimatchedwa mapulogalamu a mankhwala. Masiku ano, izi ndizizindikiro zomwe zimangophatikiza anthu omwe ali ndi metastases otsimikizika, tikudikirira nthawi yomwe titha kuchedwetsa mawonekedwe a metastases pogwiritsa ntchito mankhwalawa.
Kodi kupezeka kwamankhwala amakono kumawoneka bwanji m'maiko ena a European Union?
M'mayiko ambiri a EU, mankhwala atsopano a mahomoni amapezeka atangolandira chithandizo kusiyana ndi ku Poland.
Chifukwa chiyani mumalingaliro anu chithandizo chatsopano cha khansa ya prostate sichikubwezeredwa ndipo kodi pali mwayi uliwonse wosintha posachedwa?
Sindikupeza yankho ku funso loyamba, ndipo lachiwiri: Ndikukhulupirira.