Purpura fulminans ndi matenda opatsirana omwe amaimira mtundu woopsa kwambiri wa sepsis. Zimayambitsa magazi kuundana ndi minofu necrosis. Nthawi zambiri amayamba chifukwa cha matenda a meningococcal ndipo zotsatira zake zimakhala zakupha ngati sizikusamaliridwa pakapita nthawi.

Kutentha kwakukulu, kuwonongeka kwakukulu kwa chikhalidwe, kusanza ndi kupweteka kwa m'mimba ndizo zizindikiro zoyamba zosadziwika bwino. Madontho amodzi kapena angapo ofiira ndi ofiirira amafalikira mwachangu pakhungu, nthawi zambiri pamiyendo yapansi. Ichi ndi purpura, kutuluka magazi pakhungu. Kupanikizika pakhungu sikumatsitsa magazi ndipo sikumapangitsa kuti banga lizimiririka kwakanthawi, chizindikiro cha "extravasation" ya magazi mu minofu. Izi ndichifukwa choti Purpura Fulminans imayambitsa kufalikira kwa intravascular coagulation (DIC), komwe ndiko kupanga timadontho tating'ono tomwe timasokoneza magazi (thrombosis), kuwalozera ku dermis ndikupangitsa kutuluka kwa magazi ndi necrosis ya minofu yapakhungu. Matenda opatsirana amatha kutsagana ndi kugwedezeka kapena kusokonezeka kwa chidziwitso cha munthu wokhudzidwayo.

Nthawi zambiri, purpura fulminans imalumikizidwa ndi matenda oopsa komanso owopsa a bakiteriya. Neisseria meningitidis (meningococcus) ndiye kachilombo kofala kwambiri komwe kamayambitsa matenda, pafupifupi 75% ya milandu. Chiwopsezo chokhala ndi purpura fulminans chimapezeka mu 30% ya matenda a meningococcal (IIMs). (2) 1 mpaka 2 milandu ya IMD pa 100 okhalamo imachitika chaka chilichonse ku France, ndi kufa kwa milandu pafupifupi 000%. (10)

Mabakiteriya ena amatha kukhala ndi udindo wopanga purpura fulminans, monga Streptococcus pneumoniae (pneumococcus) kapena Haemophilus influenzae (Bacillus ya Pfeiffer). Nthawi zina chifukwa chake ndi kusowa kwa mapuloteni C kapena S, omwe amathandizira pakuphatikizana, chifukwa cha kusakhazikika kwa chibadwa: kusintha kwa jini ya PROS1 (3q11-q11.2) ya protein C ndi PROC gene (2q13-q14) kwa mapuloteni C. Tiyenera kukumbukira kuti purpura fulgurans imatha chifukwa cha matenda ochepa kwambiri monga nkhuku, nthawi zambiri.

Purpura fulminans imatha kukhudza zaka zilizonse, koma makanda osakwana zaka 15 ndi achinyamata azaka 20 mpaka 1 ali pachiwopsezo chachikulu. (XNUMX) Anthu omwe adalumikizana kwambiri ndi munthu yemwe wakhudzidwa ndi vuto la septic ayenera kulandira chithandizo chamankhwala kuti apewe kutenga matenda.

Chidziwitsochi chikugwirizana mwachindunji ndi nthawi yomwe yatengedwa kuti mutenge ulamuliro. Purpura fulminans imayimiradi vuto lazachipatala lachangu kwambiri lomwe limafunikira chithandizo chamankhwala mwachangu momwe mungathere, osadikirira chitsimikiziro cha matendawa komanso osatsatiridwa ndi zotsatira zoyambirira za chikhalidwe chamagazi kapena kuyezetsa magazi. Purpura yokhala ndi malo osachepera amodzi okhala ndi mainchesi akulu kuposa kapena ofanana mamilimita atatu, iyenera kuyambitsa chenjezo ndi chithandizo nthawi yomweyo. Chithandizo cha maantibayotiki chiyenera kukhala choyenera pa matenda a meningococcal ndi kuchitidwa kudzera m'mitsempha kapena, kulephera, intramuscularly.