Kuphatikizika kwa in vitro feteleza

Dongosolo la chithandizo cha umuna mu m'mimba limafunikira nthawi zambiri ndi akatswiri, omwe amakonzekeretsa awiriwa za njirayi. Banja liyenera kuphunzitsidwa za njira zovuta mongajakisoni wa m`thupi mankhwala, zoopsa ndi Zotsatira zoyipa, komanso nthawi yodikira zofunika. Mankhwalawa ndi okwera mtengo.

Ku Quebec, kuyambira 2010, Régie de l'Assurance Maladie (RAMQ) yakhazikitsa Quebec Assisted Procreation Programme yomwe imapereka kwaulere mitundu yonse ya mautumiki okhudzana ndi kusabereka, kuphatikizapo mtengo wa maulendo atatu olimbikitsa.⁹.

Ku France, mayesero 4 a umuna mu vitro amaperekedwa mokwanira ndi Health Insurance.

1. Kukondoweza kwa thumba losunga mazira

Gawo loyamba ndikupatsa mkazi chithandizo cha mahomoni, nthawi zambiri GnRH agonist (Gonadotropin Kutulutsa Hormone) pofuna kupumitsa mazira ochuluka (onani gawo la mankhwala), mwachitsanzo Decapeptyl®, Suprefact®, Enantone® Synarel®, kapena Lupron®.

Ndiye, mankhwala ndiye cholinga kuonjezera chiwerengero cha follicles opangidwa ndi ovary ndikuwongolera nthawi ya ovulation. Mayi ayenera kulandira jakisoni wa ma gonadotropin okhala ndi FSH kapena LH kuti alimbikitse minyewayo kuti ikule ndikupangitsa kuti ipange ma oocyte angapo. Izi ndi mwachitsanzo Puregon®, Gonal F®, Fostimon® Metrodin-HP®, Bravelle®, Humegon® Ménopur® Merional® Repronex® Fertinex® Fertinorm®, Humegon® Ménopur® Merional® Repronex® Fertinex® Fertinorm®, Elonva®, Luvéris®…

Pamene follicles yakula mokwanira ndipo ma hormone ali okwanira, ovulation imayambitsidwa ndi jekeseni wa hormone HCG.Gonadotropin ya Chorionic ya Anthu), mwachitsanzo HCG endo 1500®, HCG endo 5000® (Fr), Pregnyl®, Choriomon®, Profasi-HP®, Chorex®, Novarel®, Ovitrelle® Ovidrel® ®

Pelvic ultrasound ndi kuyezetsa magazi kumachitika pa sitepe iliyonse kuti awone kukula kwa follicle.

Palibenso ma follicles, palibenso mazira ...

Nthawi zambiri thumba losunga mazira la amayi limabala ndi kumasulidwa dzira limodzi lokha lokhwima pa mkombero. Ngakhale kuti izi ndizokwanira kuti pakhale pathupi pabwino, kuti pakhale umuna wabwino wa umuna, payenera kupezeka mazira okhwima kwambiri. Choncho m`pofunika yotithandiza wodwalayo yamchiberekero ntchito mwamphamvu kuposa masiku onse. Mankhwala omwe amaperekedwa panthawi ya in vitro fertilization amayambitsa kukula kwa multiple ovarian follicles, motero kuonjezera chiwerengero chotheka cha mazira, motero mwayi wopeza mwana wosabadwayo.

2. Kusonkhanitsa ma oocyte okhwima

Pambuyo pa maola 32 mpaka 36 akukondoweza kwa mahomoni, ma oocyte akupsa amatengedwa pogwiritsa ntchito chubu chaching'ono ndi singano yomwe imalowetsedwa kumaliseche. Izi zimachitidwa pansi pa anesthesia wamba kapena wamba ndi ultrasound control chifukwa zingakhale zowawa kwambiri. Kenako ma oocyte amasankhidwa mu labotale.

Le umuna amatengedwa maola angapo zisanachitike (kapena kusungunuka tsiku lomwelo), ndipo umuna umasiyanitsidwa ndi madzi a umuna ndikusungidwa pa 37 ° C.

3. Kubereketsa

Maola angapo pambuyo pokolola, spermatozoa ndi oocyte zimayikidwa mu madzi a chikhalidwe kwa maola angapo kutentha kwa thupi. Umuna wa spermatozoa umabwera modzidzimutsa, popanda thandizo lakunja, pokhudzana ndi oocyte. Koma umuna umodzi wokha ndi umene ungabereke umuna umenewu. Ambiri, pafupifupi, 50% ya oocyte amapangidwa ndi umuna.

Ma oocyte (kapena ma zygote) amayamba kuchulukana. Pamaola 24, ma zygote amasanduka miluza ya ma cell awiri kapena anayi.

4. Kusintha kwa mluza

Patangotha ​​masiku awiri kapena asanu kuchokera pamene umuna wakumana, mluza umodzi kapena awiri amasamutsidwira kuchiberekero cha mkazi. Kusamutsa mwana wosabadwayo ndi njira yosavuta komanso yosapweteka yomwe imachitika pogwiritsa ntchito katheta kakang'ono komanso kofewa kamene kamalowetsa kumaliseche kumaliseche. Mluza umayikidwa mkati mwa chiberekero ndipo umakulirakulirabe mpaka kuyikidwa.

Pambuyo pa sitepe iyi, amayi nthawi zambiri amatha kuyambiranso ntchito zake zachizolowezi.

Miluza imodzi kapena zingapo (zotchedwa supernumeraries) zimathanso kusungidwa ndi kuzizira kuti ziyesedwe mtsogolo.

Pambuyo pake, dokotala akhoza kupereka chithandizo chamankhwala cha mahomoni, komanso zolemba zoyezetsa mimba kuti awone ngati IVF yakhala yothandiza.

Mankhwala angapo nthawi zina amafunikira mimba isanayambe. Ndipo n’zomvetsa chisoni kuti okwatirana ena satenga mimba ngakhale kuti ayesetsa kangapo.

Malangizo asanafike IVF: 

• Siyani kusuta (mwamuna ndi mkazi!), Chifukwa amachepetsa kwambiri mwayi wokhala ndi pakati.
• Chitani masewera olimbitsa thupi ndikuyesetsa kuti mukhale ndi thanzi labwino. Zimathandizira kukhala ndi chonde chabwino.
• Kwa amayi: imwani vitamini B9 musanatenge mimba, chifukwa izi zimachepetsa chiopsezo cha malformation mwa mwana wosabadwa.
• Pezani kuwombera chimfine (zingayambitse kupititsa padera).