Asayansi ochokera ku Lodz University of Technology apanga njira yatsopano ya hydrogel yochizira mabala a matenda a shuga. Kuvala kumapereka tetrapeptide ku chilonda chomwe chingabwezeretse ndikupanga mitsempha yatsopano yamagazi mkati mwake.
Malinga ndi ochita kafukufuku, kugwiritsa ntchito chovala choterechi kungachepetse chiwerengero cha anthu odulidwa.
Kuchiza zilonda za matenda a shuga panopa ndi vuto lalikulu ku Poland komanso padziko lonse lapansi kusiyana ndi kuchiza zilonda zamitundu ina. Mtengo wamankhwala otere komanso zotsatira za mabala a matenda a shuga ndizokwera kwambiri - pachifukwa ichi ku Poland chithandizo chamankhwala chopitilira 10 chimachitika chaka chilichonse. kudulidwa chiwalo. Chifukwa cha kutsimikizika kwa zilondazi, palibe biomaterials yomwe idapangidwa padziko lapansi zomwe zingawonjezere kwambiri mwayi wochiritsidwa.
Timu ya Prof. Janusz Rosiak wochokera ku Interdepartmental Institute of Radiation Technology ya Lodz University of Technology wapanga ukadaulo wopanga ma hydrogel mavalidwe opangidwa ndi tetrapeptide, omwe amayambitsa angiogenesis, mwachitsanzo, kubwezeretsa ndikupanga mitsempha yatsopano yamagazi mkati mwa bala. Kuyesa kwa ma cell a biomatadium kumapereka zotsatira zabwino.
Zovalazo zidapangidwa potengera chovala cha hydrogel chopangidwa ndi asayansi ochokera ku Łódź, omwe - malinga ndiukadaulo wawo - adapangidwa padziko lonse lapansi kwazaka zopitilira 20. Lili ndi katundu wa chovala choyenera, ndipo chifukwa chake, zotsatira zabwino zimatheka pochiza zilonda zamoto, zilonda zam'mimba ndi zilonda zomwe zimakhala zovuta kuchiza, monga zilonda za trophic.
Kuvala kwa Hydrogel kumayikidwa mwachindunji pabala, kuphatikiza. imapereka mpweya wolowera pachilonda, imakhala chotchinga motsutsana ndi matenda akunja, imayamwa ma exudates, imapereka malo onyowa, imachepetsa ululu, imachotsa minofu ya necrotic pachilonda ikachotsedwa pabala. Panthawi imodzimodziyo, zimakhala zotheka kumwa mankhwala osokoneza bongo (pamenepa tetrapeptide) nthawi zonse, mlingo wokhazikika, popanda kufunikira kwa dokotala.
Zikuoneka kuti yankho limene tapanga lingakhale lothandiza kwambiri pochiza zilonda za matenda a shuga. Mtengo wopangira zovalazo ndi wotsika kwambiri, ndipo kupanga kwake kumatha kuchitika popanda ndalama zazikulu - adauza PAP, wopanga zovala, Prof. Janusz Rosiak.
Kuvala pochiza zilonda za matenda a shuga pakalipano kumafuna kuyambika kwa mayesero a preclinical ndi chipatala, omwe - monga Prof. Rosiak - salipidwa ndi boma. Ndicho chifukwa chake tili okonzeka kugwirizana ndi makampani omwe ali ndi chidwi ndi kupanga zovala zoterezi - anawonjezera.
Panthawi yamankhwala ndi chovala chapamwamba cha hydrogel chomwe chimapangidwa molingana ndi njira ya Rosiak, zidapezeka kuti zimakhala ndi phindu pamankhwala omwe amatchedwa phazi la matenda ashuga, koma mwayi wochiritsa chilonda chamtunduwu pogwiritsa ntchito kuvala kotereku. pafupifupi 50 peresenti. - monganso mitundu ina ya zovala zomwe zimadziwika ndi kugwiritsidwa ntchito padziko lapansi.
Izi zikugwirizana ndi kutsimikizika kwa mabala a shuga, monga amasiyanitsidwa, mwa zina, necrosis ya minofu ya bala chifukwa cha kuwonongeka ndi kuwonongeka kwa mitsempha. Zimagwirizananso ndi kuwonongeka kwa minofu yamanjenje ndi kufa kwapang'onopang'ono kwa minofu yozungulira bala.
Kuyesa kuchiza zilonda zamtunduwu, zomwe zimachitika ku Poland komanso padziko lonse lapansi, zimatengera kuzindikira mtundu wa matenda a bakiteriya ndi kugwiritsa ntchito maantibayotiki kapena zinthu zina zomwe zingathandize kuti bala likhale loyera. Poyembekezera chilonda kuti chichiritse, zinthu zomwe zingayambitse angiogenesis, mwachitsanzo, kubwezeretsa ndi kupanga mitsempha yatsopano yamagazi mkati mwa bala, ikhoza kuperekedwa kwa icho. Chifukwa chaichi, ntchito angapo zinthu, otchedwa kukula zinthu.
Prof. Rosiak anafotokoza kuti mu kafukufuku wawo, asayansi ochokera ku Łódź anakumana ndi malipoti m'mabuku okhudza kugwiritsa ntchito tetrapeptide yosavuta kuti apangitse angiogenesis powapereka kumalo ochiritsidwa a thupi. Ndi gulu lomwe limapangidwa mwachilengedwe m'thupi la munthu, lomwe lili ndi theka la moyo wa mphindi 5, chifukwa chake kukhazikika kwake m'thupi lomwe limagwira ntchito kumakhala kotsika kwambiri. Tetrapeptide iyi yalembetsedwa ngati mankhwala ndikuvomerezedwa ndi US Food and Drug Administration (FDA).
Komabe, makonzedwe ake ku minofu yozungulira balalo adachitidwa ndi jekeseni, zomwe zinapangitsa kuti zikhale zosatheka kulamulira malo ochitirapo kanthu ndikuyambitsa zotsatira zake - kufika mofulumira kwambiri komanso kutayika mofulumira, zomwe zimawononga zotsatira zake zochiritsira. Lingaliro lathu loyambirira, pamlingo wapadziko lonse lapansi, limatha kuyesa kuphatikiza kuvala kwa hydrogel ndi tetrapeptide iyi - adalongosola wasayansiyo.
Ukadaulo wopangira chovala cha hydrogel chopangidwa ndi ofufuza a Łódź umakhala ndi kusakaniza kosakaniza kwa mavalidwe m'madzi (madzi amakhala opitilira 90% ya kapangidwe kake), ndiyeno atayiyika m'phukusi ndikutseka, ndikuyimitsa ndi madzi. electron mtengo. Zotsatira zake, chigamba cha hydrogel chosabala chimapangidwa chomwe chimagwiritsidwa ntchito ngati chovala.
Vuto la kafukufuku linali loti ngati chinthu chogwira sichingawonongeke panthawi yotseketsa, chifukwa tetrapeptide mu njira yamadzimadzi mothandizidwa ndi mtengo wa elekitironi imawonongedwa kale pamiyeso ya ma elekitironi yomwe sinatsimikizirebe kuuma kwa mankhwalawa. Komabe, tinakwanitsa kuthetsa vutoli - anawonjezera Prof. Rosiak.
Yankho linaperekedwa kuti litetezedwe ku Ofesi ya Patent. Chifukwa cha thandizo lazachuma la National Center for Research and Development, asayansi ochokera ku Lodz adachita kafukufuku wokhudza kutulutsidwa kwa tetrapeptide pachilonda, kulimba kwake pakuvala (itha kugwiritsidwa ntchito ngakhale chaka chimodzi pambuyo pake) ndi kulumikizana ndi ma cell.
Pa mlingo wa maselo, tinatsimikizira kufotokoza kwa majini omwe amachititsa angiogenesis, ndipo pa mlingo wa ma cellular, kuwonjezereka kwakukulu kwa kuchuluka kwa maselo a endothelial. Tidawonetsanso kudalira kwa zotsatira zomwe zapezeka pazambiri za tetrapeptide ndipo tidatsimikiza mulingo woyenera - pulofesa adati.
Asayansi alengeza kuti ngati sapeza gwero la ndalama zopititsira patsogolo kafukufuku wokhudza kavalidwe kawo, saletsa kuti adziwitsa anthu za kavalidwe kawo. Vuto la kuchiza phazi lotchedwa matenda a shuga limakhudza anthu padziko lonse lapansi ndipo sitiyenera kupanga ndalama pa izo - akukhulupirira Prof. Rosiak. (PAP)