Kuchuluka kwa uric acid kungadziwike m'magazi kapena mkodzo. Kuonjezera apo, ndi chizindikiro cha gout, kumwa mowa kwambiri kapena kulephera kwa impso.

Uric acid ndi a zonyansa wa thupi. Mwachindunji, ndiye mapeto akuchotsa mamolekyu otchedwa nucleic acid ndi purines.

Nthawi zambiri, uric acid wambiri m'thupi la munthu amasungunuka m'magazi ndikulowa mu impso kuti achotsedwe mumkodzo. Koma nthawi zina, thupi limatulutsa uric acid wochuluka kapena kulephera kuchotsa mokwanira. Matendawa amatha kuyambitsa matenda osiyanasiyana.

Uric acid ndiye gawo lomaliza la kuwonongeka kwa thupi kugona, mlingo wake umasiyana malinga ndi zomwe zili mu purine m'thupi. Ndipo zikuwonekeratu kuti purines amapezeka makamaka muzakudya. 

Zina mwazakudya zomwe zili ndi purines zomwe muyenera kuzipewa ndi izi:

• anchovies, hering'i, mackerel, sardines, shrimps, etc;
• chiwindi, mtima, ubongo, impso, buledi, etc;
• nandolo, nyemba zouma, etc.

Kumwa mowa, makamaka mowa, sikuvomerezeka mukafuna kuchepetsa uric acid.

M'malo mwake, pakati pa zakudya zololedwa zomwe zili ndi purine, tikhoza kutchula:

• tiyi, khofi, zakumwa zoziziritsa kukhosi;
• zipatso ndi masamba ;
• mazira ;
• mkate ndi chimanga;
• tchizi ndi zambiri za mkaka

Chifukwa chiyani muyeso wa uric acid?

Dokotala amalembera kuyezetsa magazi (kotchedwa uricemia) ndi / kapena kuyesa kwa mkodzo wa uric acid kwa:

• kudziwa gout;
• kuunika momwe impso zikuyendera bwino;
• itha kupemphedwanso pakachitika mimba;
• kapena mwa anthu onenepa kwambiri.

Onani kuti kusanthula ndende ya uric acid mu mkodzo kudzakuthandizaninso kumvetsa bwino chiyambi cha mkulu mlingo wa uric asidi m'magazi.

M'magazi, kuchuluka kwa uric acid kumakhala pakati pa 35 ndi 70 mg / L.

Kuchuluka kwa uric acid m'magazi kumatchedwa hyperuricemia ndipo zingayambitsidwe ndi kuchulukitsidwa kwa uric acid m'thupi kapena kuchepa kwa kuchotsedwa kwake ndi impso. Chifukwa chake, kuchuluka kwa uric acid m'magazi kumatha kukhala chizindikiro cha:

• gout (ichi ndicho chifukwa chachikulu cha kuchuluka kwa uric acid m'magazi);
• kuwonjezereka kwa kuwonongeka kwa mapuloteni a chamoyo chomwe chimachitika, mwachitsanzo, panthawi ya chemotherapy, leukemia kapena lymphoma;
• uchidakwa;
• kuchita masewera olimbitsa thupi mopitirira muyeso;
• kukhalapo kwa miyala ya impso;
• kuwonda mofulumira;
• shuga;
• zakudya zokhala ndi purine;
• preeclampsia pa nthawi ya mimba;
• kapena kulephera kwa impso.

M'malo mwake, ndizotheka kuti mulingo wa uric acid m'magazi ndi wocheperako kuposa momwe zimakhalira, koma izi ndizovuta kwambiri kuposa momwe zimakhalira.

Chifukwa chake, milingo ya uric acid pansi pazabwinobwino imatha kukhala yokhudzana ndi:

• zakudya zochepa za purine;
• Matenda a Wilson (matenda a chibadwa omwe mkuwa umalowa m'thupi);
• impso (monga Fanconi syndrome) kapena kuwonongeka kwa chiwindi;
• kapena ngakhale kukhudzana ndi mankhwala oopsa ( lead ).

Mumkodzo, kuchuluka kwa uric acid kumakhala pakati pa 250 ndi 750 mg / maola 24.

Dziwani kuti mayendedwe abwinobwino amatha kusiyanasiyana pang'ono kutengera ma laboratories omwe akuwunika.

Kukhudza 5 mpaka 15% yaanthu, ndizovuta zomwe zimachitika chifukwa cha kuchuluka kwa uric acid komanso / kapena kuchepa kwa aimpso. Nthawi zambiri imayamba mosapweteka ndipo sichidziwika nthawi zonse.

Kuchuluka kwa uric acid kumatha kufotokozedwa motere:

Idiopathic kapena primary hyperuricemia

Iwo amaimira unyinji wa milandu. Zotengera zobadwa nazo zimapezeka mu 30% ya anthu, koma nthawi zambiri zimagwirizanitsidwa ndi kunenepa kwambiri, kudya kwambiri, kuthamanga kwa magazi, kumwa mowa mwauchidakwa, matenda a shuga ndi hypertriglyceridemia.

Zosowa za enzyme

Amapezeka makamaka ku matenda a Von Gierke ndi matenda a Lesch-Nyhan. Matenda a enzymatic awa amakhala ndi vuto loyambitsa matenda a gout msanga, mwachitsanzo, m'zaka 20 zoyambirira za moyo.

Hyperuricemia yachiwiri ku matenda kapena mankhwala.

Izi zitha kukhala chifukwa cha hyperuricemia:

- kusowa kwa kuchotsa uric acid. Izi ndizochitika chifukwa cha kulephera kwa impso, komanso chifukwa cha mankhwala ena (ma diuretics, komanso mankhwala otsekemera komanso mankhwala ena oletsa chifuwa chachikulu).

- kuwonjezeka kwa kuwonongeka kwa nucleic acid. Izi timaziwona mu matenda a magazi (leukemia, hemopathies, hemolytic anemia, psoriasis yambiri), komanso zotsatira za mankhwala ena a khansa.

Zotsatira za hyperuricemia

Hyperuricemia ingayambitse mitundu iwiri ya mavuto:

• Gout yomwe imayambitsa ululu wamtundu wotupa.

Pamene ma microcrystals a uric acid osungunuka m'magazi ali ochuluka kwambiri ndipo mikhalidwe ya m'deralo imakhala yabwino (makamaka acidity yokwanira ya sing'anga), imathamanga ndikuyambitsa kutupa kwanuko. Izi makamaka zimakhudza olowa chala chachikulu chala. Munthu mmodzi yekha mwa 1 aliwonse omwe ali ndi uric acid wochulukira m'magazi awo angadwale gout, ndiye kuti mumafunika kukhala pachiwopsezo chowonjezereka kuti mutenge.

• Mkodzo lithiasis.

Iwo ali chifukwa cha kukhalapo kwa mwala umodzi kapena angapo mu mkodzo thirakiti ndipo ndi udindo aimpso colic. Urolithiasis ndi matenda ofala kwambiri chifukwa 1 mpaka 2% ya anthu amakhudzidwa ku France.

Kuwunika kwa acidity imodzi kumatha kuchitika m'magazi ndi / kapena mkodzo:

• kuyezetsa magazi kumakhala ndi magazi a venous, nthawi zambiri m'chigongono;
• mlingo wa uric acid mu mkodzo umayesedwa pa maola 24: kuchita izi, ndikokwanira kukodza mu chidebe choperekedwa ndi cholinga ichi ndikuperekedwa ndi ogwira ntchito zachipatala kwa tsiku limodzi ndi usiku umodzi.

Dziwani kuti ndi bwino kusadya kapena kumwa kalikonse m'maola oyambirira mayesowo.

Pali zinthu zambiri zomwe zingakhudze kuchuluka kwa uric acid m'magazi kapena mkodzo. Izi zikuphatikizapo:

• zakudya (zosauka kapena zochulukira mu purines);
• mankhwala (kusaina gout, aspirin, kapena okodzetsa);
• zaka, ana omwe ali ndi makhalidwe ochepa;
• jenda, pomwe akazi amakhala ndi chiwopsezo chochepa kuposa amuna;
• kulemera, anthu onenepa kukhala ndi mlingo wapamwamba.

Chithandizo cha mankhwala ngati hyperuremia ndi symptomatic ndi motere: 

• Nucleic acid synthesis reducers, monga allopurinol. Muyenera kukhala tcheru kwambiri chifukwa pali zambiri kugwirizana ndi mankhwala ena.
• Mankhwala omwe amalepheretsa aimpso uric acid reabsorption, monga benzbromarone.
• Mankhwala a Enzymatic omwe nthawi zambiri amayambitsa zovuta za ziwengo.

Zirizonse zomwe zingachitike, ndi dokotala yemwe ayenera kusankha ngati chithandizo chiyenera kutsatiridwa, ndipo chomwe chili choyenera kwambiri.