vitamini B9

Zothandiza ndi zotsatira pathupi

Ubwino wa vitamini B9 m'thupi:

• zimakhudza nthawi yolera wathanzi komanso kukula koyenera kwa mwana wosabadwa: folic acid imalepheretsa kukula kwa zolakwika mu dongosolo la mwana wosabadwayo, wochepa thupi, wobadwa msanga, ndipo izi zimachitika koyambirira kwa mimba.
• antidepressant: folic acid imaganiziridwa kuti imathandizira kuthana ndi kukhumudwa ndikusintha malingaliro.
• Amathandiza mu mapuloteni kagayidwe.
• Kulimbana: Vitamini B9 imawerengedwa kuti ndi antioxidant yamphamvu yomwe imathandizira kutulutsa poizoni mthupi ndikuwongolera khungu.
• Kusunga Mtima Wathanzi: Kugwiritsa ntchito folic acid kumachepetsa magazi a homocysteine, omwe amatha kukwezedwa ndipo atha kukuyikani pachiwopsezo cha matenda amtima. Kuphatikiza apo, mavitamini a B, omwe amaphatikizapo folic acid, amachepetsa chiopsezo cha chitukuko.
• Kuchepetsa chiopsezo cha khansa: Pali umboni woti kuchepa kwamankhwala kumalumikizidwa ndikukula kwa khansa ya m'mawere mwa amayi.

Kupatsidwa folic acid kagayidwe mu thupi

Folate imagwira ntchito ngati coenzyme mu nucleic acid kaphatikizidwe ndi amino acid metabolism. Kamodzi m'thupi, zakudya zam'madzi zimasungunuka motengera monoglutamate m'matumbo zisanatengeke ndi zinthu zonyamula zodutsa kudzera mu mucous membrane. Asanalowe m'magazi, mawonekedwe a monoglutamate amachepetsedwa kukhala tetrahydrofolate (THF) ndikusandulika methyl kapena formyl form. Njira yayikulu yopangira plasma ndi 5-methyl-THF. Folic acid imapezekanso yosasintha m'magazi (unmetabolized folic acid), koma sizikudziwika ngati mawonekedwe awa ali ndi zochitika zilizonse zachilengedwe.

Kuti ma folate ndi ma coenzymes ake adutse khungu, otumiza apadera amafunika. Izi zikuphatikiza kuchepa kwa transporter (RFC), proton yonyamula folate transporter (PCFT), ndi mapuloteni amtundu wa receptor, FRα ndi FRβ. Folate homeostasis imathandizidwa ndikuchulukirachulukira kwa otumiza anzawo, ngakhale kuchuluka kwawo ndi tanthauzo lake zimasiyanasiyana m'matumba osiyanasiyana mthupi. PCFT imagwira gawo lofunikira pakusintha kwamunthu chifukwa kusintha komwe kumakhudza PCFT komwe kumayambitsa kubadwa kwa folate. Kulephera kwa PCFT kumapangitsanso kusunthika kwa mayendedwe a folate kupita kuubongo. FRa ndi RFC ndizofunikanso kuti mayendedwe amtundu wodutsa pakati pa dongosolo loyendetsa magazi ndi dongosolo lamanjenje chapakati. Tsamba ndilofunikira pakukula koyenera kwa mluza ndi mwana wosabadwayo. The placenta amadziwika kuti ndi amene amachititsa kuti folate itulutse mwana, zomwe zimapangitsa kuti mwana akhale ndi zibadwa zambiri kuposa mayi. Mitundu itatu yonse ya zolandilira imalumikizidwa ndi mayendedwe amtundu wodutsa pa placenta panthawi yapakati.

Kuyanjana ndi micronutrients ena

Folate ndi pamodzi zimapanga imodzi mwamagulu amphamvu kwambiri a micronutrient. Kugwirizana kwawo kumathandizira njira zina zofunika kwambiri pakugawikana kwa maselo ndi kubwerezabwereza. Komanso, iwo pamodzi nawo mu kagayidwe homocysteine. Ngakhale kuti mavitamini awiriwa angapezeke mwachibadwa kuchokera ku mitundu iwiri yosiyana ya zakudya (vitamini B12 - kuchokera ku nyama: nyama, chiwindi, mazira, mkaka, ndi vitamini B9 - kuchokera ku masamba a masamba, nyemba), ubale wawo ndi wofunika kwambiri. kwa thupi. Amakhala ngati cofactors mu synthesis ya methionine kuchokera ku homocysteine. Ngati kaphatikizidwe sichichitika, ndiye kuti mulingo wa homocysteine ​​​​ukhoza kukwezedwa, womwe nthawi zambiri umalumikizidwa ndi chiopsezo cha matenda amtima ndi sitiroko.

Kuyanjana kwamagetsi mu vitamini B9 kumachitika ndi riboflavin (). Yotsirizira ndi kalambulabwalo wa coenzyme nawo folate kagayidwe. Amasintha mtundu wa folate kukhala mawonekedwe ake, 5-methyltetrahydrofolate.

Zitha kuchepetsa kuchepa kwa chilengedwe cha folate coenzymes ndi folic acid m'mimba ndikupangitsa kuti bioavailability ipangidwe.

Zakudya zophatikiza kwambiri ndi vitamini B9

Vitamini B9 imathandiza kuphatikiza ndi mavitamini ena a B.

Mwachitsanzo, mu saladi yokhala ndi kale, mbewu za mpendadzuwa, feta, balere, anyezi wofiira, nandolo, peyala, ndi mavalidwe a mandimu. Saladi wotereyu amapatsa thupi mavitamini B3, B6, B7, B2, B12, B5, B9.

Chakudya chabwino cham'mawa kapena chamasana ndi sangweji yopangidwa ndi mkate wonse wa tirigu, nsomba yosuta, katsitsumzukwa, ndi mazira. Chakudyachi chili ndi mavitamini monga B3 ndi B12, B2, B1 ndi B9.

Chakudya ndiye gwero labwino kwambiri la mavitamini. Chifukwa chake, kuthekera kwakumwa mavitamini monga mankhwala kuyenera kuganiziridwa ngati pali zisonyezo zoyenera. Pali umboni kuti kukonzekera kwa vitamini, ngati kugwiritsidwa ntchito molakwika, sikuti kumangopindulitsa, komanso kumatha kuvulaza thupi.

Gwiritsani ntchito mankhwala

Pregnancy

Folic acid imagwiritsidwa ntchito ngati mankhwala pazifukwa zambiri. Choyamba, amapatsidwa kwa amayi apakati ndi omwe akukonzekera kutenga pakati. Kukula ndi kukula kwa mwana wosabadwayo kumadziwika ndi kugawikana kwama cell. Miyezo yokwanira yofunikira ndiyofunikira kwambiri pakupanga kwa DNA ndi RNA. Chifukwa chosowa folic acid, pakati pa masiku a 21 ndi 27 atatenga pathupi, matenda amatchedwa neural chubu chilema… Monga mwalamulo, panthawiyi, mayi samadziwa kuti ali ndi pakati ndipo sangatengepo mbali moyenera powonjezera kuchuluka kwa zakudya m'zakudya. Matendawa amabweretsa zovuta zingapo pamitunduyi - kuwonongeka kwa ubongo, encephalocele, zotupa zamtsempha.

Vuto lobadwa nalo pamtima ndi lomwe limayambitsa kufa kwa ana ndipo limathandizanso kuti munthu akamwalira akhale wamkulu. Malinga ndi European Registry of Congenital Anomalies and Gemini, kumwa osachepera 400 mcg wa folic acid patsiku mwezi umodzi asanatenge pathupi komanso kwa masabata 8 pambuyo pake kunachepetsa chiopsezo cha kubadwa kwa mtima ndi 18%.

Maseŵera a amayi omwe ali ndi amayi angapangitse chiopsezo chotenga matenda obadwa nawo. Kafukufuku ku Norway adawonetsa kuti kumwa mankhwala owonjezera mavitamini okhala ndi ma mcg osachepera 400 amachepetsa kuchepa kwa mkamwa ndi 64%.

Kulemera kochepa kubadwa kumalumikizidwa ndi chiopsezo chowonjezeka chakufa mchaka choyamba cha moyo ndipo kumakhudzanso thanzi la munthu atakula. Kuwunika mwatsatanetsatane kwaposachedwa ndikuwunika meta kwamaphunziro asanu ndi atatu owongoleredwa kuwonetsa kuyanjana kwabwino pakati pa kudya ndi kulemera kwakubadwa.

Kuchuluka kwa magazi a homocysteine ​​kumathandizidwanso ndi kuchulukana kwa padera komanso zovuta zina za pakati, kuphatikiza preeclampsia ndi kuphulika kwapakhosi. Kafukufuku wamkulu wofufuza zakumbuyo adawonetsa kuti kuchuluka kwa plasma homocysteine ​​mwa azimayi kumakhudza mwachindunji kupezeka kwa zovuta zoyambira ndi zovuta, kuphatikiza preeclampsia, preterm labour, komanso kuchepa kwambiri. Malangizo a homocysteine, nawonso, amapezeka ndi folic acid.

Chifukwa chake, ndikwanzeru kutenga folic acid, moyang'aniridwa ndi adotolo, panthawi yonse yoyembekezera, ngakhale utsekere wa neural utatsekedwa, kuti muchepetse mavuto ena panthawi yapakati. Kuphatikiza apo, kafukufuku waposachedwa sanapeze umboni uliwonse wokhudzana ndi kudya pakati pa folate panthawi yapakati komanso zovuta paumoyo wa ana, makamaka kukula kwa I.

Matenda a mtima

Kafukufuku wopitilira 80 akuwonetsa kuti ngakhale kuchuluka kwamagazi okwanira a homocysteine ​​kumawonjezera chiopsezo cha matenda amtima. Makina omwe homocysteine ​​angapangitse kuti chiwopsezo cha matenda opatsirana achuluke akadafufuzidwabe, koma atha kuphatikizanso zovuta zoyipa za homocysteine ​​pakumanga magazi, kusungunuka kwamitsempha, ndikukhazikika kwamakoma azitsulo. Zakudya zolemera zamankhwala zimalumikizidwa ndi kuchepa kwa matenda amtima, kuphatikiza myocardial (mtima) ndi stroke. Kafukufuku wa amuna 1980 ku Finland pazaka 10 zapitazi adapeza kuti omwe amadya zakudya zambiri amakhala ndi chiopsezo chochepa cha 55% chodwala matenda amtima mwadzidzidzi poyerekeza ndi omwe samadya pang'ono. Mwa mavitamini atatu a B omwe amayang'anira kuchuluka kwa ma homocysteine, folate yawonetsedwa kuti imathandizira kwambiri kutsika kwa basal, bola kulibe vuto la vitamini B12 kapena vitamini B6. Kuchulukitsa kudya kwa folate kuchokera ku zakudya zopatsa thanzi kapena zowonjezera kumapezeka kuti kwachepetsa kuchuluka kwa homocysteine.

Ngakhale pali kutsutsana pankhani yakuchepetsa homocysteine ​​popewa matenda amtima, kafukufuku wowerengeka adawunika zomwe zingachitike chifukwa cha folate supplementation, yomwe imadziwika kuti ndi chiopsezo cha matenda amitsempha. Ngakhale mayesero aposachedwa sanawonetse kuti mbiri yakale imatchinjiriza thupi, kudya pang'ono pamankhwala kumadziwika kuti ndi chiwopsezo cha matenda amtima.

Cancer

Khansa imaganiziridwa kuti imayambitsidwa ndi kuwonongeka kwa DNA chifukwa cha njira zochulukitsira za DNA, kapena kuwonetsa kolakwika kwa majini ofunikira. Chifukwa chofunikira kwambiri pakapangidwe ka DNA ndi RNA kapangidwe kake, ndizotheka kuti mavitamini B9 osakwanira amathandizira kukulitsa kusakhazikika kwa majini ndi zolakwika za chromosome zomwe nthawi zambiri zimakhudzana ndi kukula kwa khansa. Makamaka, kubwereza ndi kukonza kwa DNA ndikofunikira kwambiri kuti matupi athu akhalebe, ndipo kusowa kwa ma nucleotide omwe amayamba chifukwa cha kusowa kwa folate kumatha kubweretsa kusakhazikika kwa ma genome ndikusintha kwa DNA. Tsamba limayang'aniranso kayendedwe ka homocysteine ​​/ methionine ndi S-adenosylmethionine, wopereka methyl wama methylation. Chifukwa chake, kusowa kwa folate kumatha kusokoneza DNA ndi protein methylation ndikusintha mawonekedwe amtundu womwe umakhudzidwa ndikukonzanso kwa DNA, kugawa kwa maselo ndi kufa. Global DNA hypomethylation, chizindikiro cha khansa, imayambitsa kusakhazikika kwa ma genome komanso ma chromosomal fractures.

Kugwiritsa ntchito zipatso ndi ndiwo zamasamba zosachepera kasanu patsiku kwakhala kukucheperachepera masiku ano. Zipatso ndi ndiwo zamasamba ndizomwe zimayambira, zomwe zitha kuthandizira pakuthana ndi khansa.

Matenda a Alzheimer ndi dementia

Matenda a Alzheimer ndiwo mawonekedwe ofala kwambiri. Kafukufuku wina adapeza kuyanjana pakati pa kuchuluka kwa zipatso ndi ndiwo zamasamba zomwe zili ndi folate komanso kuchepa kwa amayi.

Chifukwa cha ntchito yake pakuphatikizika kwa ma acid amadzimadzi ndikupereka methyl yokwanira pamachitidwe a methylation, folate imakhudza kukula bwino ndi magwiridwe antchito aubongo, osati panthawi yapakati komanso yobereka, komanso m'moyo. Pakafukufuku wina wamagulu azimayi achikulire, odwala matenda a Alzheimer's anali ndi milingo yayikulu kwambiri ya homocysteine ​​komanso kuchuluka kwamagazi poyerekeza ndi anthu athanzi. Kuphatikiza apo, wasayansiyo adamaliza kunena kuti milingo yayitali yamagazi, m'malo mogwiritsa ntchito posachedwapa, ndi omwe amathandizira kupewa matenda amisala. Kafukufuku wazaka ziwiri, wosasinthika, wowongolera ma placebo mwa odwala 168 okalamba omwe ali ndi vuto lakuzindikira pang'ono amapeza phindu lodya tsiku lililonse 800 mcg folate, 500 mcg vitamini B12, ndi 20 mg vitamini B6. Atrophy ya madera ena aubongo omwe amakhudzidwa ndi matenda a Alzheimer adawonedwa mwa magulu onse awiriwa, ndipo atrophy iyi idalumikizidwa ndikuchepa kwazindikiritso; komabe, gululi lomwe limathandizidwa ndi mavitamini a B silinataye kwenikweni poyerekeza ndi gulu la placebo (0,5% motsutsana ndi 3,7%). Zopindulitsa kwambiri zidapezeka mwa odwala omwe ali ndi magawo oyambira kwambiri a homocysteine, ndikuwonetsa kufunikira kochepetsa kufalikira kwa homocysteine ​​popewa kuzindikira komanso kuchepa kwa malingaliro. Ngakhale zili ndi chiyembekezo cholimbikitsira, vitamini B-supplementation iyenera kufufuzidwanso m'maphunziro akulu omwe amafufuza zotsatira za nthawi yayitali, monga matenda a Alzheimer's.

Kusokonezeka maganizo

Maseŵera otsika akhala akugwirizanitsidwa ndi kuvutika maganizo ndi kusayankha bwino kwa mankhwala opatsirana pogonana. Kafukufuku waposachedwa wa anthu awiri azaka za 2 mpaka 988 ku United States adapeza kuti seramu ndi maselo ofiira am'magazi anali ochepa kwambiri mwa anthu omwe anali atapanikizika kwambiri kuposa omwe anali asanakhalepo ndi nkhawa. Kafukufuku mwa amuna ndi akazi 1 omwe amapezeka kuti ali ndi vuto la kukhumudwa adapeza kuti 39 mwa odwala 52 okha omwe ali ndi vuto lochepa amathandizidwa ndi mankhwala opondereza, poyerekeza ndi 1 mwa odwala 14 omwe ali ndi magawo abwinobwino.

Ngakhale kuti folic acid yowonjezerapo sananene kuti ingalowe m'malo mwa mankhwala opatsirana pogonana, atha kukhala othandiza ngati cholumikizira. Pakafukufuku waku UK, odwala 127 omwe adasokonezeka adasankhidwa kuti atenge 500 mcg wa folate kapena placebo kuphatikiza 20 mg ya fluoxetine (antidepressant) tsiku lililonse kwamasabata 10. Ngakhale zovuta zomwe amuna anali nazo sizowerengera kwenikweni, azimayi omwe adalandira fluoxetine kuphatikiza folic acid adachita bwino kwambiri kuposa omwe adalandira fluoxetine kuphatikiza placebo. Olemba kafukufukuyu anazindikira kuti kulemba "nthabwala" kumatha kuthandizanso pakuthandizira kuchipatala. "

Mlingo wa mavitamini B9

Fomu yofala kwambiri ya folic acid ndi mapiritsi. Mlingo wa vitamini ukhoza kukhala wosiyana, kutengera cholinga cha mankhwalawo. Mavitamini a amayi apakati, omwe amapezeka kwambiri ndi 400 mcg, popeza kuchuluka kwake kumawerengedwa kuti ndikwanira kukula kwa mwana wosabadwayo. Nthawi zambiri folic acid imaphatikizidwa m'mavitamini, pamodzi ndi mavitamini ena a B. Maofesi oterewa amatha kukhala ngati mapiritsi, komanso mawonekedwe amatawuni, mapiritsi osungunuka, komanso jakisoni.

Kuchepetsa milingo ya homocysteine, nthawi zambiri 200 mcg mpaka 15 mg ya folate imaperekedwa patsiku. Pochiza kukhumudwa, tengani mavitamini 200 mpaka 500 a mavitamini patsiku, kuwonjezera pa chithandizo chachikulu. Mlingo uliwonse uyenera kuperekedwa ndi adokotala.

Folic acid mu mankhwala amwambo

Asing'anga, monga madotolo azachipatala, amazindikira kufunikira kwa folic acid kwa amayi, makamaka amayi apakati, komanso gawo lawo popewa matenda amtima ndi kuchepa kwa magazi.

Folic acid imapezeka, mwachitsanzo, mkati. Zipatso zake zimalimbikitsidwa ku matenda a impso, chiwindi, mitsempha yamagazi ndi mtima. Kuphatikiza pa folate, strawberries amakhalanso ndi tannins, potaziyamu, chitsulo, phosphorous, cobalt. Pazamankhwala, zipatso, masamba ndi mizu imagwiritsidwa ntchito.

Folate, pamodzi ndi mafuta ofunikira, vitamini C, carotene, flavonoids ndi tocopherol, amapezeka mumbeu. Chomeracho chimakhala ndi bile komanso diuretic, chimathandizira kupuma ndi kuyeretsa thupi. Kulowetsedwa ndi kutsekedwa kwa njere kumathandiza ndi kutukusira kwa nembanemba yam'mimba yamikodzo. Kuphatikiza apo, kumulowetsa parsley chifukwa cha magazi a uterine.

Gwero lolemera la folic acid mu mankhwala owerengeka amalingaliridwa. Amakhala ndi madzi 65 mpaka 85%, shuga 10 mpaka 33 peresenti, ndi zinthu zambiri zothandiza - zidulo zosiyanasiyana, tannins, potaziyamu, magnesium, calcium, manganese, cobalt, chitsulo, mavitamini B1, B2, B6, B9, A, C, K, P, PP, michere.

Kafukufuku waposachedwa pa vitamini B9

• Kugwiritsa ntchito folic acid kambiri sikungayambitse chiopsezo chotenga preeclampsia. Ndi matenda aakulu omwe amadziwika ndi kukula kwa kuthamanga kwa magazi kwambiri panthawi yoyembekezera komanso mavuto ena. Matendawa ndi owopsa kwa mayi ndi mwana. Zanenedwa kale kuti kumwa kwambiri mankhwala kumachepetsa chiopsezo chokhala ndi akazi omwe ali ndi matendawa. Ena mwa iwo ndi omwe amadwala matenda a kuthamanga kwa magazi nthawi zonse; akazi akudwala kapena; woyembekezera amapasa; komanso omwe adakhalapo ndi preeclampsia m'mimba zam'mbuyomu. Kafukufukuyu adaphatikiza azimayi opitilira 2 zikwi omwe anali ndi pakati pakati pa milungu 8 ndi 16. Zinapezeka kuti kutenga 4 mg ya folic acid tsiku lililonse sikunakhudze chiopsezo chokhala ndi matendawa poyerekeza ndi omwe adatenga malowa m'malo mwa 1 mg ya folate (14,8% yamilandu ndi 13,5% yamilandu , motsatana). Komabe, madotolo amalimbikitsabe kumwa mankhwala ochepa asanachitike komanso panthawi yoyembekezera kuti athetse matenda obadwa nawo.
• Asayansi aku Ireland atsimikiza kuti anthu ambiri opitilira 50 ali ndi vitamini B12 (1 mwa anthu 8) ndipo amadzipangira (1 mwa anthu 7). Kuchepa kwakusowa kumasiyanasiyana ndi moyo, thanzi komanso thanzi. Mavitamini onsewa ndiofunikira pa thanzi lamanjenje, ubongo, kupanga maselo ofiira ofiira, komanso kugawanika kwa DNA. Zinapezekanso kuti kuchuluka kwa kusowa kwaulemu kumawonjezeka ndi zaka - kuyambira 14% pakati pa anthu azaka 50-60, mpaka 23% mwa iwo azaka zopitilira 80. Amapezeka nthawi zambiri mwa osuta, anthu onenepa komanso omwe amakhala okha. Kulephera kwa Vitamini B12 kunali kofala kwambiri kwa iwo omwe amasuta (14%), amakhala okha (14,3%), komanso mwa anthu ochokera kumayiko otsika pachuma.
• Asayansi aku Britain amaumirira kulemeretsa ufa ndi zakudya zina ndi folic acid. Malinga ndi omwe adalemba kafukufukuyu, tsiku lililonse ku Britain, pafupifupi, azimayi awiri amakakamizidwa kuchotsa mimba chifukwa cha vuto la neural tube, ndipo ana awiri amabadwa ndi matendawa sabata iliyonse. Britain ndi amodzi mwamayiko omwe kulimbikitsidwa kwawo sikofala, mosiyana ndi United States ndi mayiko ena. Pulofesa Joan Morris anati: “Ngati dziko la Britain likanaloleza kuti boma lizikhala ndi mpanda wolimba kwambiri mu 1998, monga ku America.

Gwiritsani ntchito cosmetology

Folic acid imagwira ntchito yofunika kwambiri. Ili ndi ma antioxidants ambiri omwe amachepetsa ntchito ya makutidwe ndi okosijeni komanso amalepheretsa anthu kusintha zinthu mwaulere pano. Katemera wa folic acid amathandizanso kuti khungu lizikhala loyenda bwino polimbitsa chotchinga cha khungu. Izi zimakola chinyezi ndikuchepetsa kuuma.

Muzodzoladzola, mankhwala a folate nthawi zambiri amaphatikizidwa mumafuta odzola ndi mafuta opaka, omwe, akagwiritsidwa ntchito pamutu, amatha kuthandizira kuwongolera bwino komanso mawonekedwe akhungu.

Kugwiritsa ntchito ziweto

Kuperewera kwa folic acid kwapezeka koyesera m'mitundu yambiri ya nyama, yomwe imawonetsedwa ngati kuchepa kwa magazi m'thupi, kuchepa kwa kuchuluka kwa leukocyte. Makamaka minofu yomwe imakula kwambiri kapena kupangika kwa minofu imakhudzidwa, monga nembanemba yam'mimba, epidermis ndi mafupa. Mu agalu ndi amphaka, kuchepa kwa magazi nthawi zambiri kumafanana ndi kusowa kwa folate komwe kumayambitsidwa ndi matumbo a malabsorption syndromes, kuperewera kwa zakudya m'thupi, otsutsana ndi folate, kapena kuchuluka kwa zofunikira za folate chifukwa chotaya magazi kapena hemolysis. Kwa nyama zina monga nkhumba, anyani ndi nkhumba, kukhala ndi gawo lokwanira pazakudya ndikofunikira. Mwa nyama zina, kuphatikiza agalu, amphaka, ndi makoswe, folic acid yopangidwa ndi m'matumbo microflora nthawi zambiri imakhala yokwanira kukwaniritsa zosowa. Chifukwa chake, zizindikilo zakusowa kumatha kukula ngati mankhwala opatsirana m'mimba amaphatikizidwanso muzakudya kuti zilepheretse kukula kwa bakiteriya. Kuperewera kwamankhwala kumachitika agalu ndi amphaka, nthawi zambiri ndimatenda opha tizilombo. Zikuwoneka kuti zambiri zofunika tsiku lililonse pazolemba zimakwaniritsidwa ndi kaphatikizidwe kabakiteriya m'matumbo.

Contraindications ndi kusamala

Pafupifupi 50-95% ya folic acid imawonongeka pophika ndi kuteteza. Zotsatira za kuwala kwa dzuwa ndi mpweya ndizovulaza zochitika. Sungani zakudya zapamwamba kwambiri mu chidebe chakuda chakuda kutentha.

Zizindikiro zakusowa kwa folate

Zofooka za folic acid zokha ndizosowa ndipo nthawi zambiri zimalumikizidwa ndi zina zoperewera chifukwa cha kuperewera kwa zakudya m'thupi kapena matenda oyamwa. Zizindikiro nthawi zambiri zimakhala kufooka, kuvuta kuyang'ana, kukwiya, kugunda kwa mtima, komanso kupuma movutikira. Kuphatikiza apo, pakhoza kukhala zowawa ndi zilonda pa lilime; mavuto ndi khungu, tsitsi, misomali; mavuto m'mimba; kuchuluka kwa homocysteine ​​m'magazi.

Zizindikiro za mavitamini B9 owonjezera

Kawirikawiri, kudya mopitirira muyeso kulibe vuto lililonse. Nthawi zambiri, kuchuluka kwambiri kwa ma folate kumatha kuwononga impso ndikuwononga njala. Kutenga vitamini B9 wambiri kumatha kubisa kusowa kwa vitamini B12. Mlingo wokhazikika wa tsiku ndi tsiku wa munthu wamkulu ndi 1 mg.

Mankhwala ena amakhudza kuyamwa kwa vitamini B9 m'thupi, pakati pawo:

• kulera pakamwa;
• methotrexate (yogwiritsidwa ntchito pochiza khansa ndi matenda amthupi);
• antiepileptic mankhwala (phenytoin, carbamazepine, valproate);
• sulfasalazine (amagwiritsidwa ntchito pochiza ulcerative colitis).

Werengani komanso za mavitamini ena: