Kutanthauzidwa ndi kukhalapo kwa acidity yambiri m'magazi, acidosis ndizomwe zimachitika chifukwa cha zovuta zama metabolic ndi matenda omwe acidity ochulukirapo amapangidwa. Nthawi zina zimakhala zadzidzidzi. Ulamuliro wake umachokera kuchiza chifukwa chake. 

Kukhalapo kwa metabolic acidosis m'thupi kumalumikizidwa ndi kuwonjezeka kwa kupanga kapena kuyamwa ma acid ndi / kapena kuchepa kwa ma acid. Nthawi zina zimakhalanso zotsatira za kuwonongeka kwa kugaya chakudya kapena impso za ma bicarbonates (HCO3-) omwe nthawi zambiri amalepheretsa kupezeka kwa asidi m'magazi ndikutenga nawo gawo pamlingo wa acid-base.

Nthawi zambiri, madzi a m'magazi (gawo la magazi opanda maselo ofiira a magazi, maselo oyera a magazi ndi mapulateleti) ndi madzi osalowerera ndale, ndiye kuti, amakhala ndi ma ionic ambiri omwe amatsutsa (HCOE-, H +, Na +, K +), CL-…). Ndipamene milandu yabwino ikachulukirachulukira pomwe metabolic acidosis imachitika.

Pali zifukwa zambiri za metabolic acidosis. Metabolic acidosis si matenda pawokha, koma mawonekedwe achilengedwe a kusalinganika kwa magazi pakati pa acidity ndi bicarbonates. Kusalinganika uku ndi zotsatira za zovuta zingapo zomwe zingatheke.

Kukhalapo kwa lactic acid wambiri mwa kudzikundikira m'magazi

Izi organic metabolic acidosis zimachitika chifukwa cha: 

• chikhalidwe cha physiological shock; 
• kulephera kwa chiwindi (chiwindi sichigwiranso ntchito zake zoyeretsa magazi);
• matenda a magazi monga pachimake leukemia kapena lymphoma (khansa ya mwanabele);
• matenda a impso (impso sizichotsanso asidi ochulukirapo m'magazi); 
• poizoni wa chakudya (methanol, salicylates, ethylene glycol, etc.);
• ketoacidosis (matenda a shuga pamene insulini yatha).

Kukhalapo kwa lactic acid wambiri m'magazi mwa kuchepetsa kuchotsedwa kwake

Izi mineral metabolic acidosis zimachokera ku:

• pachimake aimpso kulephera;
• kuchuluka kwa NaCl chloride kulowetsedwa (mchere);
• kutayika kwa bicarbonate mu impso;
• kutaya kwa bicarbonate kuchokera m'mimba (kutsekula m'mimba);
• adrenal insufficiency.

Metabolic acidosis imatha kuchitikanso pakulephera kwambiri kupuma komwe thupi silingathenso kuchotsa mpweya woipa kudzera m'mapapo, zomwe zimapangitsa kuti madzi a m'magazi azikhala acidity. Acidosis imatchedwa "kupuma".

Mlingo wa acid-base m'thupi ukakhumudwa mosasamala kanthu za zomwe zimayambitsa, zizindikiro zosiyanasiyana zimatha kuwonetsedwa. Ngati kusalinganikaku kuli kocheperako, sipadzakhala zizindikiro kupatulapo zomwe zimayambitsa (kutsekula m'mimba, kusapeza bwino komwe kumakhudzana ndi matenda a shuga, etc.). Koma kusalinganika kumachulukitsidwa (pH <7,10), zizindikiro zotsatirazi zitha kuchitika:

• chisokonezo;
• kusanza;
• kusamva bwino;
• kuchuluka kupuma (polypnea pofuna kuthetsa owonjezera kagayidwe acidity);
• kutsika kwa magazi (hypotension) kapena ngakhale kugwedezeka kwamtima ndi mtima wosakhazikika komanso chikomokere.

Acidosis iyi ikapezeka mosadukiza (kulephera kupuma kwanthawi yayitali…), imatha kuchititsa kuti m'kupita kwanthawi kashiamu achoke m'mafupa (osteoporosis, rickets).

Kupitilira kufunafuna chomwe chimayambitsa ndi kuyezetsa kowonjezera, kuyezetsa magazi pamlingo wa mitsempha yoyezera mpweya wamagazi ndi ma electrolyte a seramu kumapangitsa kuti zitheke kuwunikira zotsatira zachilengedwe za metabolic acidosis.

Zomwe zimayambitsa metabolic acidosis zidzakayikiridwa ndi mbiri yachipatala (shuga, kupuma, aimpso kapena kulephera kwa chiwindi ...) komanso ndikuwunika kwachilengedwe komwe kumawona kuchuluka kwa shuga m'magazi, chiwindi ndi aimpso, sodium ndi chlorine wamagazi, kapena mankhwala oopsa magazi (methanol, salicylate, ethylene glycol).

Chithandizo cha kagayidwe kachakudya acidosis ndizomwe zimayambitsa (matenda a shuga osakhazikika, kutsegula m'mimba, chiwindi, aimpso kapena kupuma, etc.). Koma mwadzidzidzi pamene kagayidwe kake kagayidwe ka acidosis kali kwambiri, nthawi zina kumafunika kulowetsedwa kwa sodium bicarbonate kuti muchepetse acidity ya madzi a m'magazi.

Kukachitika kulephera kwaimpso kapena poizoni, hemodialysis (kusefera poizoni kuchokera m'magazi) imayeretsa magazi ndikulowa m'malo mwa impso.

Pomaliza, poyang'anizana ndi acidosis yocheperako, zakudya zimalimbikitsidwa kuti zibwezeretsenso kuchuluka kwa magazi m'magazi ndi malangizo angapo:

• sankhani zakudya zomwe zimakhala ndi zamchere (mankhwala a mandimu, tiyi ya ginger, njere za dzungu, etc.);
• kupeza mpweya wabwino pochita masewera olimbitsa thupi nthawi zonse panja;
• kutenga zowonjezera zakudya zomwe zimalimbikitsa alkalization ya magazi.