Feb. 24, 2012 - Ngakhale amagwiritsidwa ntchito kwambiri, mankhwala osagwiritsa ntchito ma antisteroidal (NSAIDs) amawoneka kuti ali pachiwopsezo ku thanzi. Zina mwazodziwika kwambiri ndi aspirin, Advil®, Antadys®, Ibuprofen® kapena Voltarene®, mankhwala omwe nthawi zambiri amapatsidwa.

Gulu ili la mankhwala odana ndi zotupa limaganiziridwa kuti litha kuvulaza mtima ndi impso. Zowonadi, ma NSAID adasungidwa ndi:

• Matenda a mtima

Kuti athetse ululu, mankhwala osagwiritsa ntchito zotupa omwe amaletsa kutupa amaletsa kugwiritsa ntchito michere iwiri (= mapuloteni omwe amalola zochita zamagetsi) zotchedwa COX-1 ndi COX-2.

Kuletsa COX-2 ndi ma NSAID kumateteza magazi kusakanikirana komanso kaphatikizidwe ka ma thromboxanes, mahomoni omwe ali ndi gawo la vasoconstrictor, motero kumawonjezera kuthamanga kwa magazi komanso kuwopsa kwa mtima.

• Zilonda ndi kutuluka m'mimba

COX-1 imalola mapangidwe a prostaglandins, ma metabolites omwe amapangidwa mu ndulu, impso ndi mtima. Kuletsa kwa COX-1 ndi mankhwala osagwiritsidwa ntchito poletsa kutupa kumalepheretsa kuteteza m'mimba, ndipo zimatha kuyambitsa zilonda zam'mimba.

• Aimpso kulephera

Kuletsa kwa COX-1 kulimbikitsanso kulephera kwa impso pochepetsa kufinya kwa impso.

Mwambiri, ndi okalamba omwe amakhudzidwa kwambiri ndi zoopsazi, chifukwa ntchito yawo yaimpso imachepa, chododometsa, pomwe timadziwa kuti mankhwala odana ndi zotupa amafunsidwa kuti athetse ululu wokhudzana ndi osteoarthritis.

Anaïs Lhôte - PasseportSanté.net

Source: Mankhwala anu, Philippe moser