Kuzindikira kwa acromegaly ndikosavuta (koma kokha mukaganizira), popeza kumaphatikizapo kuyezetsa magazi kuti mudziwe kuchuluka kwa GH ndi IGF-1. Mu acromegaly, pali mlingo waukulu wa IGF-1 ndi GH, podziwa kuti kutsekemera kwa GH nthawi zambiri kumakhala kosalekeza, koma kuti mu acromegaly nthawi zonse imakhala yokwera chifukwa sichikulamulidwanso. Kuzindikira kotsimikizika kwa labotale kumatengera kuyesa kwa glucose. Popeza glucose nthawi zambiri amachepetsa katulutsidwe ka GH, kuwongolera pakamwa kwa glucose kumapangitsa kuti zitheke, poyesa magazi motsatizana, kuti, mu acromegaly, kutulutsa kwa timadzi tating'onoting'ono kumakhalabe kokwera.

Pamene hypersecretion ya GH yatsimikiziridwa, ndiye kuti ndikofunikira kupeza chiyambi chake. Masiku ano, muyezo wa golide ndi MRI yaubongo yomwe ingawonetse chotupa cha pituitary gland. Nthawi zambiri, ndi chotupa chomwe chili kwina (nthawi zambiri mu ubongo, mapapo kapena kapamba) chomwe chimatulutsa timadzi tambiri tomwe timagwira pa pituitary gland, GHRH, yomwe imathandizira kupanga GH. Kuwunika kowonjezereka kumachitidwa kuti apeze magwero a katulutsidwe kameneka.