Chifukwa chafupipafupi chofunsira, hyperandrogenism imatanthawuza kuchulukitsa kwa mahomoni achimuna mwa mkazi. Izi zimawonetseredwa ndi zizindikiro zambiri kapena zochepa za virilization.

Kwa amayi, mazira ndi adrenal glands mwachibadwa amapanga testosterone, koma pang'ono. Nthawi zambiri amapezeka pakati pa 0,3 ndi 3 nanomoles pa lita imodzi ya magazi, poyerekeza ndi 8,2 mpaka 34,6 nmol / L mwa anthu.

Timalankhula za hyperandrogenism pamene mlingo wa hormone iyi ndi wapamwamba kuposa momwe timakhalira. Zizindikiro za virilization zitha kuwoneka: 

• hyperpilosis;
• ziphuphu;
• dazi;
• hypertrophy ya minofu, etc.

Zotsatira zake sizongokongoletsa zokha. Zingakhalenso zamaganizo ndi zamagulu. Kuphatikiza apo, kuchulukitsa kwa testosterone kumatha kuyambitsa kusabereka komanso zovuta za metabolism.

Zitha kufotokozedwa ndi zifukwa zosiyanasiyana, zofala kwambiri ndi izi.

Ovarian dystrophy

Izi zimatsogolera ku polycystic ovary syndrome (PCOS). Izi zimakhudza pafupifupi amayi amodzi mwa 1 aliwonse. Odwala amazindikira matenda awo akadali achichepere, akafunsa za vuto la hyperpilosity ndi ziphuphu zakumaso, kapena pambuyo pake, akakumana ndi kusabereka. Izi ndichifukwa choti ma testosterone ochulukirapo omwe amapangidwa ndi thumba losunga mazira amasokoneza kukula kwa ma ovarian follicles, omwe sakhwima mokwanira kuti amasule mazira. Izi zimawonetsedwa ndi kusokonezeka kwa msambo, kapena ngakhale kusowa kwa msambo (amenorrhea).

Congenital adrenal hyperplasia

Matenda osowa majiniwa amachititsa kuti ma adrenal asamagwire bwino ntchito, kuphatikizapo kuchulukitsidwa kwa mahomoni achimuna komanso kuperewera kwa cortisol, timadzi timene timagwira ntchito yaikulu mu metabolism ya chakudya, mafuta ndi mapuloteni. Pankhaniyi, hyperandrogenism imatsagana ndi kutopa, hypoglycemia ndi kutsika kwa magazi. Matendawa nthawi zambiri amawonekera kuyambira kubadwa, koma nthawi zina zocheperako amatha kudikirira mpaka munthu wamkulu kuti adziwulule. 

Chotupa pa adrenal gland

Zosowa kwambiri, zimatha kuyambitsa kutulutsa kwambiri kwa mahomoni aamuna, komanso cortisol. Hyperandrogenism imatsagana ndi hypercorticism, kapena Cushing's syndrome, gwero la kuthamanga kwa magazi.

Chotupa cha ovarian chomwe chimatulutsa mahomoni achimuna

Koma chifukwa chake ndi chosowa.

kusintha kwa thupi

Pamene kupanga kwa mahomoni achikazi kumachepa kwambiri, mahomoni achimuna amakhala ndi mpata wochuluka wodziwonetsera. Nthawi zina izi zimabweretsa kusokoneza, ndi zizindikiro zazikulu za virilization. Kuwunika kwachipatala kokha komwe kumakhudzana ndi kuyezetsa kwa mahomoni, ndi mlingo wa androgens, kungatsimikizire matendawa. Ultrasound ya thumba losunga mazira kapena adrenal glands ingathenso kulamulidwa kuti ifotokoze chifukwa chake.

Zizindikiro za hyperandrogenism ndi izi:

• chiwonedwe : tsitsi ndilofunika. Makamaka, tsitsi limapezeka m'madera a thupi lomwe nthawi zambiri limakhala lopanda tsitsi mwa amayi (nkhope, torso, m'mimba, m'munsi, matako, ntchafu zamkati), zomwe zimatha kukhala ndi vuto lalikulu la maganizo ndi chikhalidwe. ;
• ziphuphu zakumaso et seborrhee (khungu lamafuta); 
• alopecia dazi lachimuna, lomwe lili ndi tsitsi lodziwika bwino pamwamba pamutu kapena kutsogolo.

Zizindikirozi zimathanso kulumikizidwa ndi:

• matenda a msambo, ndi kusowa kwa msambo (amenorrhea), kapena nthawi yayitali komanso yosakhazikika (spaniomenorrhea);
• kukula kwa clitoral (clitoromegaly) ndi kuchuluka kwa libido;
• zizindikiro zina za virilization : liwu likhoza kukhala lovuta kwambiri ndipo minofu imakumbukira maonekedwe a amuna.

Zikadziwika kwambiri, hyperandrogenism imatha kuyambitsa zovuta zina zazitali:

• zovuta za metabolic : kuchulukitsa kwa mahomoni achimuna kumalimbikitsa kunenepa komanso kukula kwa insulin kukana, motero chiopsezo cha kunenepa kwambiri, shuga ndi matenda amtima;
• gynecological mavuto, kuphatikizapo chiopsezo chowonjezeka cha khansa ya endometrial.

Ichi ndichifukwa chake hyperandrogenism siyenera kuganiziridwa kokha kuchokera kuzinthu zodzikongoletsera. Zingafunike chithandizo chamankhwala.

Kuwongolera kumadalira poyamba pa zonse zomwe zimayambitsa.

Ngati chotupa

Opaleshoni imafunika kuchotsa.

Kwa polycystic ovary syndrome

Palibe chithandizo choletsa kapena kuchiza matendawa, koma chithandizo chazizindikiro zake.

• Ngati wodwalayo satero kapena ana ambiri, chithandizocho chimaphatikizapo kuika thumba losunga mazira kuti lipume, kuchepetsa kupanga kwawo kwa mahomoni achimuna. Mapiritsi a estrogen-progestin amalembedwa. Ngati izi sizikukwanira, mankhwala odana ndi androgen amatha kuperekedwa ngati chowonjezera, cyproterone acetate (Androcur®). Komabe, popeza mankhwalawa posachedwapa agwirizanitsidwa ndi chiopsezo cha meningioma, kugwiritsidwa ntchito kwake kumangokhala pazochitika zovuta kwambiri, zomwe chiŵerengero cha phindu / chiopsezo chimakhala chabwino;
• Pankhani ya chilakolako cha mimba ndi kusabereka, kukondoweza kosavuta kwa ovulation kumalimbikitsidwa ndi mzere woyamba wa clomiphene citrate. Kuwunika kwa kusabereka kumachitidwa kuti atsimikizire kusakhalapo kwa zinthu zina zomwe zikukhudzidwa. Ngati kukondoweza kwa mankhwala sikugwira ntchito, kapena ngati zinthu zina zosabereka zimapezeka, intrauterine insemination kapena in vitro fertilization imaganiziridwa. 

Kuchotsa tsitsi la laser kutha kuperekedwanso kuti muchepetse kukula kwa tsitsi komanso mankhwala am'deralo a dermatological motsutsana ndi ziphuphu.

Nthawi zonse, kuchita masewera olimbitsa thupi ndikutsata zakudya zopatsa thanzi kumalangizidwa. Pankhani ya kunenepa kwambiri, kutaya pafupifupi 10% ya kulemera koyamba kumachepetsa hyperandrogenism ndi zovuta zake zonse. 

Pankhani ya adrenal hyperplasia

Pamene matendawa ndi chibadwa, chisamaliro chapadera chimayikidwa m'malo omwe ali akatswiri a matenda osowa. Chithandizo chimaphatikizapo corticosteroids makamaka.