Makoswe ndi ma vectors akuluakulu a leptospirosis, koma nyama zina zimatha kufalitsa matendawa: nyama zina (nkhandwe, mongooses, etc.), ziweto (ng'ombe, nkhumba, akavalo, nkhosa, mbuzi) kapena kampani (agalu) ndipo ngakhale mileme. Zinyama zonsezi zimakhala ndi mabakiteriya mu impso zawo, nthawi zambiri popanda kudwala. Amanenedwa kuti ndi onyamula thanzi. Nthawi zonse anthu amaipitsidwa ndi mkodzo wa nyama zomwe zili ndi kachilomboka, kaya m'madzi kapena m'nthaka. Mabakiteriya nthawi zambiri amalowa m'thupi kudzera pakhungu pakakhala kukanda kapena kudulidwa, kapena kudzera m'mphuno, pakamwa, m'maso. Mukhozanso kutenga matenda mwa kumwa madzi kapena chakudya chomwe mabakiteriya alipo. Nthawi zina ndi kukhudzana mwachindunji ndi kachilombo nyama kuti kuyambitsa matenda.