Rhabdomyolysis ndi mawu omwe amawonetsa kuwonongeka kwa minofu. Pali zifukwa zingapo za rhabdomyolysis iyi, zotsatira zake zimakhala zovuta kwambiri kutengera komwe kumayambitsa matendawa.

Mawu akuti rhabdomyolysis amapangidwa ndi suffix -lyse kutanthauza chiwonongeko, ndi mawu akuti rhabdomyo- kutanthauza kuti chigoba striated minofu, ndiko kunena kuti minofu yonse ya thupi la munthu kupatula minofu yamtima (myocardium) ndi minofu yosalala (yomwe imagwiritsidwa ntchito. luso loyendetsa modzidzimutsa monga luso la m'mimba kapena mitsempha yamagazi).

Maselo a minofu akawonongeka, mamolekyu ambiri amatulutsidwa m’magazi. Chimodzi mwa izi ndi puloteni yomwe imapezeka m'maselo a minofu. Ndi creatine phosphokinase, yomwe imatchedwa CPK. Molekyu iyi imayesedwa m'zochitika zamakono. Mlingo wokwera kwambiri, ndiye kuti rhabdomyolysis imakulirakulira.

Zomwe zimayambitsa rhabdomyolysis ndizosiyanasiyana. Tiyambiranso apa mndandanda wosakwanira wazomwe zimayambitsa rhabdomyolysis:

Trauma / compression

Kuponderezana kwa mwendo, mwachitsanzo, matenda a crush, pomwe munthu amakakamira pansi pagalimoto kapena pansi pa chivomezi, kumayambitsa rhabdomyolysis yomwe nthawi zambiri imakhala yowopsa.

Kusasunthika kwanthawi yayitali kumayambitsa kupsinjika kwa minofu komwe kungayambitse rhabdomyolysis (kutayika kwa chidziwitso, opaleshoni yayitali, ndi zina).

Kuchulukana kwa minofu

• Matenda a khunyu
• Kuchita masewera olimbitsa thupi (marathon, ultra-trail)

matenda

• Viral: chimfine
• Bakiteriya: legionellosis, tularemia
• Matenda: malungo, trichinellosis

Kutentha kwakukulu

• Neuroleptic malignant syndrome
• Kutentha kwa mpweya
• Malignant hyperthermia

Toxic

• mowa
• Cocaine
• Heroin
• Amphetamines

Mankhwala

• Odwala
• Statins

Sungani bwino

• Polymyosite
• Dermatomyosite

Genetics

Nthawi zina, nkhani yake ndi yodziwikiratu, mwachitsanzo pa kusweka kapena kukomoka kwa nthawi yayitali.

Nthawi zina, zizindikiro za kuwonongeka kwa minofu zimakhala zovuta kuziwona. Kupweteka kwa minofu kumatha kukhala ndi ululu wamtundu wa kuuma kapena kupweteka kwa minofu pa palpation. Pakhoza kukhala edema ya minofu yomwe ingayambitse matenda a compartment. Nthawi zina chizindikiro chokha cha minofu ndikumva kufooka kwa minofu.

Nthawi zina chizindikiro kwa dokotala ndi kusintha kwa mtundu wa mkodzo. M'malo mwake, myoglobin yomwe imatulutsidwa ndi maselo amtundu wa mkodzo wofiyira kutembenukira bulauni (kuyambira Ice-Tea mpaka Coca-Cola).

Kuzindikira kwa rhabdomyolysis kumakhazikitsidwa ndi kuyesa kwa CPK. Timalankhula za rhabdomyolysis ngati ma CPK ndi apamwamba kasanu kuposa momwe timakhalira.

Vuto lalikulu la rhabdomyolysis ndi kulephera kwaimpso pachimake. Izi ndizambiri koma timawona kawopsedwe ka myoglobin ndi kudzikundikira kwake m'mitsempha yaimpso zomwe zimapangitsa kuti mkodzo utsekeke. Kulephera kwa aimpso kumatha kutsagana ndi zovuta za metabolic, kuphatikiza hyperkalemia. Hyperkalemia ndi kuchuluka kwa potaziyamu m'magazi. Vutoli likhoza kupha imfa ngati potaziyamu sabwereranso m'magazi momwe angathere m'magazi mwamsanga. Izi nthawi zambiri zimafuna kugwiritsa ntchito dialysis.

Zotsatira zina, zomwe tazitchula kale ndi compartment syndrome. Ndiko kupindika kwa zigawo za minofu. Izi zimawonetseredwa ndi ululu wopweteka kwambiri ndi edema yopweteka ya minofu. Kuwonongeka kwa opaleshoni yotchedwa "discharge aponeurotomy" kuyenera kuchitidwa mwamsanga, kamodzi kokha matenda a compartment atsimikiziridwa.

Monga tawonera kale, zomwe zimayambitsa rhabdomyolysis ndizosiyana kwambiri. Mankhwalawa mwachionekere amadalira chifukwa chake.

Nthawi zambiri, chithandizo cha rhabdomyolysis chimafuna kupewa zovuta.

Pofuna kupewa kulephera kwakukulu kwaimpso, kubwezeretsedwa kokwanira kwa madzi m'thupi kuyenera kutsimikiziridwa chifukwa kutaya madzi m'thupi kumakhala pachiwopsezo cha zovuta zaimpso. Mu pachimake zinthu m`pofunika fufuzani nthawi zonse kuti potaziyamu m`magazi ndi mwa yachibadwa malire. Potsirizira pake, kuyang'anitsitsa kupweteka kwa minofu kumapangitsa kuti zitheke kufotokozera compartment syndrome.

Pomaliza, tinganene kuti pali rhabdomyolysis ndi rhabdomyolysis. Pachimake rhabdomyolysis ndi kupanikizana kwa mwendo mwachitsanzo, kungayambitse imfa. Mosiyana ndi zimenezi, rhabdomyolysis panthawi ya chimfine ndi "epiphenomenon" yomwe palibe amene angadandaule nayo. Matenda okhudzana ndi rhabdomyolysis amakhalabe osowa, kuchita masewera olimbitsa thupi kwambiri ndikofala kwambiri. Nthawi zonse ganizirani izi ndikubweretsa rhabdomyolysis pamaso pa ululu wachilendo wa minofu kapena mtundu wofiyira wofiirira wa mkodzo.